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Dysplasia

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Conjunctival dysplastic processes probably arise secondary to chronic irritative stimuli such as solar irradiation.  Clinically, these lesions are thickened and leukoplakic(#21889).  Histopathologically, the atypical cells first appear along the basal layer and then progress to involve more and more of the epithelium until the entire epithelium is replaced by abnormal cells (#21892, #21891).  The amount of cellular dysplasia can be sub-classified as mild, moderate, and severe.  Mild atypia involves less than 25-33 % of the epithelium.  Moderate atypia involves 33-75 % of the epithelium.  Severe atypia involves greater than 75% of the epithelium. 

 

Clinical #21889 High Power #21892
21889.jpg (76316 bytes) 21892.jpg (113961 bytes)
Med. Power #21891
21891.jpg (129967 bytes)
 
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