This
entity is thought to be a degenerative process that occurs in older women
and has endothelial dysfunction.Because
endothelial cells are functioning poorly and are decreased in number,
edema develops, first involving the stroma and then involving the
epithelium(#21962).Epithelial
bullae may rupture causing recurrent episodes of pain.Histopathologically, this entity is characterized by multiple
wart-like excrescences on Descemet's membrane which are called guttata
(#21964).In addition, there is a progressive loss of endothelial cells as
well as a thickening of Descemet's membrane in this entity (#21965).
