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| Herpes
simplex keratitis is usually a self-limited epithelial disease
characterized by a linear arborizing pattern of opacification and swelling
of epithelial cells with central ulceration
(dendrite formation)(#21931). When
present, two structures in the involved epithelium and superficial stroma
are diagnostic of HSV:
(1)
multinucleated giant cells and (2) intranuclear inclusions (inclusion of
Lipschutz or Type A Cowdry inclusions) which are a densely-staining mass
in the nucleus surrounded by a halo.
Cellular infiltration may be PMNs and/or chronic inflammatory
cells(#21933). A post-
herpetic ulcer and a disciform (immune disease) keratitis involve deep
stroma and, if long-standing, a granulomatous reaction along Descemet's
membrane (#21934).
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| Clinical
#21931 |
High
Power #21933 |
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| Med.
Power #21934 |
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