The
extravasation of lipid material from either blocked meibomian glands of
the tarsus or the glands of Zeis may incite a sterile foreign body
granulomatous reaction. This
often presents clinically as a painless, focal swelling in the eyelid
(#21809)(#21811). The
pathologic change is described as a lipogranuloma.
Within the granuloma, clear spaces may be seen corresponding to the
location of lipid which is dissolved during histopathologic processing
(#21813).
Foreign body giant cells (#21814), lymphocytes, plasma cells, and
PMNs may also be prominent within the lesion.
Various eyelid tumors (especially sebaceous gland carcinomas) may
mimic chalazia. A biopsy
should be performed on all recurrent or persistent chalazia to rule out
one of these lesions.
-(#28103,
#28106, #28110, #28113, #28148, #28151) are all slides of chalazion.
