Kang Zhang Curriculum Vitae

Kang Zhang, MD, PhD
Curriculum Vitae

Click to view curriculum vitae and publications as PDF (most current).

PERSONAL DATA

Name: Kang Zhang

Birth Place: China

Citizenship: United States

EDUCATION
Baccalaureate Degree

1980 - 1984 BS, Sichuan University, Sichuan, Chengdu, Biochemistry

Advanced Degree

1991 - 1995 MD, Harvard University Medical School - M.I.T., Cambridge, MA, Medicine

1985 - 1991 PhD, Harvard University, Cambridge, MA, Genetics

Resident/Fellowship Training

2002 - 2003 FELLOW, University of Utah School of Medicine, Salt Lake City, UT, Vitreoretinal Diseases and Surgery

1996 - 1999 RESIDENT, Johns Hopkins University, Wilmer Eye Institute, Baltimore, MD, Ophthalmology

1995 - 1996 INTERN, Presbyterian/St. Lukes Hospital, Denver, CO, Medicine

BOARD CERTIFICATIONS

Am Board Ophthalmology (Ophthal), 05/13/2001, Certified

National Bd Medical Examiners, 01/01/1996, Certified

CURRENT LICENSES/CERTIFICATIONS

State License (UT) 2005-2009

CS (UT) 2005-2009

DEA Certificate (UT) 2004-2009

State License (OH) 2000-2009

State License (MD) 1999-2009

ACADEMIC HISTORY

Neurobiology and Anatomy

Hire, Adjunct Track, Adjunct Assistant Professor, 01/01/2004

Ophthalmology/Visual Sciences

Hire, Tenure Track-Scientist Scholar, Assistant Professor, 03/01/2002

Promotion, Associate Professor, 07/01/2006

Tenure, 07/01/2006

PROFESSIONAL EXPERIENCE
Full Time Positions

2006 – Present Associate Professor, University of Utah, Department of Ophthalmology and Visual Science, John Moran Eye Center, Salt Lake City, UT

2002 - Present             Investigator, University of Utah, Eccles Institute of Human Genetics, Program in Human Molecular Biology & Genetics, Salt Lake City, UT

2002 - Present             Attending Staff Physician, Veteran's Administration Medical Center, Salt Lake City, UT

2002 -2006     Assistant Professor, University of Utah, Department of Ophthalmology and Visual Science, John Moran Eye Center, Salt Lake City, UT

2000 -2002     Assistant staff, Cleveland Clinic Foundation, Lerner Research Institute, Cleveland, OH

1999 -2000     Instructor, Johns Hopkins University, School of Medicine, Wilmer Eye Institute, Baltimore, MD

1999 -2000     Attending Physician, Johns Hopkins Hospital, Baltimore, MD

Editorial Experience

2001 Guest, Editorial Board for Investigative Ophthalmology and Visual Science

Reviewer Experience

Referee for American Journal of Human Genetics

Referee for American Journal of Medical Genetics

Referee for Archives of Ophthalmology

Referee for Biochemical Journal

Referee for BMC Genomics

Referee for Developmental Dynamics

Referee for Experimental Eye Research

Referee for Human Genetics

Referee for Human Molecular Genetics

Referee for International Journal of Biologic Science

Referee for Investigative Ophthalmology and Visual Science

Referee for Journal of Biological Chemistry

Referee for Journal of Cataract and Refractive Surgery

Referee for Journal of Medical Genetics

Referee for Journal of Neurology

Referee for Molecular Vision

Referee for Nature Genetics

Referee for Neuroscience

Referee for Ophthalmic Genetics

Referee for Ophthalmology

Referee for PNAS

Referee for PLoS Biology

Referee for PLoS Medicine

Referee for PLoS One

Referee for Progress in Retina and Eye Research

Referee for Retina

Referee for Trend in Genetics

RESEARCH AWARDS
Contracts

VEGF Phase III Clinical Trial for predominantly classic choroidal neovasculariation of age-related macular degeneration (ANCHOR). 06/01/2003 - 12/31/2005. Genentech Inc, Direct Costs: $633,694. Total costs: $788,160. Principal Investigator.

VEGF Phase III Clinical Trial for minimally classic and completely occult choroidal neovasculariation of age-related macular degeneration (MARINA). 08/01/2003 - 03/31/2006. Genentech Inc, Direct Costs: $686,082. Total costs: $838,321. Principal Investigator.

University of Utah PI for a multi-center study of an anti-VEGF aptamer for choroidal neovascularization from age-related macular degeneration sponsored by EyeTech pharmaceuticals and Pfizer 07/01/2001 - 07/31/2004. Eyetech Pharmaceuticals, Inc., Direct Costs: $142,647. Total costs: $180,271. Co-Investigator.

A Multicenter, Randomized, Double-Masked, Controlled Study to Evaluate Intravitreal Fluocinolone Acetonide (.5, 2, or 6 mg) Implant in Patients with Non-Infectious Uveitis Affecting the Posterior Segment of the Eye. BLP 415-001 02/01/2001 - 02/28/2005. Bausch & Lomb, Direct Costs: $164,165. Total costs: $195,498. Co-Investigator.

An open-label, multicenter extension study to evaluate the safety and tolerability of ranibizumab in subjects with choroidal neovascularization (CNV) secondary to age-related macular degeneration (AMD) who have completed the treatment phase of III Anchor or Marina trials.

09/01/2005 - present. Genentech Inc, Direct Costs: $100,500. Principal Investigator.

A Six-Month, Phase III, Multicentered, Masked, Randomized, Sham-Controlled Trial (With Six-Month Open Label Extension) To Assess the Safety and Efficacy of 700 microgram and 350 microgram Dexamethasone Posterior Segment Drug Delivery System (DEX PSDDS) Applicator System in the Treatment of Patients with Macular Edema Following Central Retinal Vein Occlusion or Branch Retinal Vein Occlusion. 04/01/2002 - . Allergan Inc, Co-Investigator.

An Evaluation of Efficacy and Safety of Posterior Juxtascleral Injections of Anecortative Acetate (15 mm) vs. Visudyne Patients with Subfoveal Exudative Age-Related Macular Degeneration (AMD). 04/01/2002 - 03/31/2006. Alcon Laboratories, Co-Investigator.

A Phase II Study of Implants of Encapsulated Human NTC-201 Cells Releasing Ciliary Neurotrophic Factor (CNTF), in Participants with Visual Acuity Impairment Associated with Atrophic Macular Degeneration (CNTF2). 08/01/2007-pres, Neurotech. Direct Costs: $300,165; Principal Investigator.

Phase II/III Study of Encapsulated Human NTC-201 Cell Implants Releasing Ciliary Neurotrophic Factor (CNTF) for Participants with Retinitis Pigmentosa Using Visual Field Sensitivity as the Primary Outcome. 08/01/2007-pres, Neurotech. Direct Costs: $90,000. Principal Investigator.

VEGF and HTRA1 DNA polymorphisms in neovascular AMD pathogenesis and response to Lucentis. Genentech. Direct Costs: $600,500. Principal Investigator.

Genetics of early to late progression of age-related macular degeneration.

Genentech. Direct Costs: $240,000. Principal Investigator.

Grants

ELOVL4 and Retinal Disease. – To characterize ELOVL4 biochemical properties and macular degeneration mechanism. R01 EY014428 05/01/2002 - 04/30/2012. National Eye Institute, Direct Costs: $250,000 per year. Total costs: $375,000 per year. Principal Investigator. .

Genetics of Macular Degeneration - To clone and characterize the disease gene for North Carolina macular dystrophy. RO1EY16698. 11/30/2003 - 07/30/2008. National Eye Institute, Direct Costs: $385,000 per year. Total costs: $580,000 per year. Principal Investigator.

Wynn Center for the Study of Retinal Degeneration (Baehr)
07/01/2005 - 06/30/2010. Foundation Fighting Blindness, Direct Costs: $45,000 per year. Total costs: $45,000 per year. Module II: Molecular genetics. Principal Investigator.

Genetics of Primary open angle glaucoma - To identify gene variants for Primary open angle glaucoma. R01EY018660-01A1. 7/1/2008 - 6/30/2013. National Eye Institute, Direct Costs: $510,000 per year. Total costs: $780,000 per year. Pending, Principal Investigator.

Genetics and Functional Studies of Age-Related Macular Degeneration- To characterize HTRA1 variants and functions in age related macular degeneration. 1R01EY018660-01A1. 7/1/2008 - 6/30/2013. National Eye Institute, Direct Costs: $250,000 per year. Total costs: $350,000 per year. Pending, Principal Investigator.

HTRA1 and age related macular degeneration. - To investigate mechanism of macular degeneration due to HTRA1. VA Merit Award. 4/1/2008 - 3/30/2012. Direct Costs: $140,000 per year. Principal Investigator.

Define novel genes for diabetic microvascular complications. –To use genetic association studies to identify genes for diabetic microvascular complications. Burroughs Wellcome Fund Clinical Scientist Award in Translational Research. 7/1/08-6/30/2013. Direct costs: $150,000 per year. Principal Investigator.

Gene Identification for Age-Related Macular Degeneration. 07/01/2005 - 06/30/2008. Knights Templar Eye Research Grant for Lejin Wang: Genetic Linkage Mapping of Leber's Congenital Amaurosis. 06/01/2005 - 06/30/2006. Knight's Templar Eye Foundation, Direct Costs: $30,000. Total costs: $30,000. Principal Investigator.

Fellowship for Nathan Faulkner: Genetic Linkage Study of a Family with Marfan Syndrome. 05/01/2005 - 09/30/2005. Fight for Sight, Inc., Direct Costs: $2,100. Total costs: $2,100. Principal Investigator.

Pharmacological intervention of retinal degeenration in ELOVL4 transgenic mice to assess drugs for retinal degeneration intervention. FR-PT-0505-0237 01/01/2005 - 12/31/2006. Foundation Fighting Blindness, Direct Costs: $119,000. Total costs: $119,000. Principal Investigator.

Gene Identification for Juvenile Retinal Dystrophy. 11/01/2003 - 10/31/2006. Macula Vision research Foundation and Ronald McDonald House Charities, Direct Costs: $80,000 per year. Total costs: $80,000 per year. Principal Investigator.

Gene Mapping for Stargardt's Macular Degeneration. 04/01/2002 - 03/31/2003. American Health Assistance Foundation, Direct Costs: $50,000. Total costs: $50,000. Principal Investigator.

Macular Degeneration Genetics. 49580-001.45 04/01/2002 - 03/31/2004. Karl Kirchgessner Foundation, Direct Costs: $50,000; Total costs: $50,000. Principal Investigator.

Gene Identification for Macular Degeneration. 04/01/2002 - 07/31/2005. Ruth and Milton Steinbach Fund, Direct Costs: $100,000 per year; Total costs: $100,000 per year. Principal Investigator.

Mentored Clinician Scientist Award K23EY00401. Project: "Cloning a gene for dominant Stargardt's disease"; Goal: to clone a gene for dominant Stargardt's disease.
08/01/1999 - 07/30/2004. National Eye Institute, Direct Costs: $175,000 per year. Total costs: $210,000. Principal Investigator.

Eye Research Award 01/01/1996 - 12/31/1996. Knight's Templar Eye Foundation, Direct Costs: $30,000. Total costs: $30,000. Principal Investigator.

SCHOLASTIC HONORS

Burroughs Wellcome Fund Clinical Scientist Award in Translational Research, 2008

Lew R. Wasserman Merit Award, Research to Prevent Blindness, 2006

Macula Society membership, 2006

American Society for Clinical Investigation membership, 2006

Ruth and Milton Steinbach Fund Award, 2003

Macula Vision Research Foundation Award, 2004

Charles Schepens Award for Excellence in Retina Research. 2001

Johns Hopkins Medical Institutions Clinician Scientist Award. 1999

Stark Research Award in Ophthalmology, Wilmer Eye Institute, Johns Hopkins University. 1998

Association of University Professors of Ophthalmology (AUPO) Inaugural Residents and Fellow's Research Forum, runner-up. 1997

Knights Templar Eye Foundation Research Award. 1996

Magna Cum Laude, Harvard Medical School. 1995

First Bower Award for Research on Macular Degeneration, Wills Eye Hospital, Philadelphia. 1993

Reed Scholar, M.I.T.. 1993 -1994

Johnson & Johnson Scholar, M.I.T.. 1991 -1992

Chinese National Scholarship for Graduate Studies Abroad. 1984

Highest Scholarships and High Distinction in Biochemistry, Sichuan Univ. 1980 -1984

ADMINISTRATIVE EXPERIENCE
Grant Review Committee/Study Section

2006-present                Ad Hoc Reviewer, Anterior Eye Disease Study Section (VISA), NIH

2006-Present   Ad Hoc Reviewer, research grants, Wellcome Trust, UK

2004                Ad Hoc Reviewer, Neurobiology C Study Section, Medical Research Service, Department of Veterans Affairs Administration

2003                Ad Hoc Reviewer, research grants, Foundation Fighting Blindness, Canada

2002 - Present             Ad Hoc Reviewer, research grants, Foundation Fighting Blindness, USA

2001                Ad Hoc Reviewer, postdoctoral training grant, Research into Aging, UK

2000                Ad Hoc Reviewer, Medical Research Service, Department of Veterans Affairs Administration

2007                Special emphasis panel, Gene environment Initiative, National Human Genome Research Institute, NIH

2007                CIDR Access Review Panel, National Human Genome Research Institute, NIH

2007                Special emphasis panel, National Eye Institute, NIH

2007                Ad Hoc Reviewer, research grants, Macular Disease Society, UK

2008                Netherlands Organisation for Health Research and Development, Netherlands

PROFESSIONAL COMMUNITY ACTIVITIES

2005              Advisory Board, Genentech, Age-related macular degeneration

2005                Co-organizer, “Genetics of Molecular Biology of Retinal Diseases”, ancillary meeting of Annual Meeting of American Society of Human Genetics, UT.

2006                Organizer, “Snowbird Neuroscience Symposium 2006”

2007              Chief Medical Editor, Ophthalmology New and World Report, China Edition.

2007       Organizing Committee member, International Forum of Vitreoretinal Diseases and Surgery, China

2007              Section Chair, Animal Model of Age-Related macular Degeneration. PreARVO Meeting 2007 on Retinal Degeneration and gene Therapy, FL.

2008              Co-organizer, Shanghai International Ophthalmology Symposium

UNIVERSITY COMMUNITY ACTIVITIES
College Level

2005 - Present    Member, SOM Academic Senate Nominating Committee, Elected appointment by the Dean

2004 - Present    Member, SOM Admissions Committee

2007-present       Member, MD-PhD program Admissions Committee

Department Level

2005 - Present    Director, Ophthalmology and Visual Sciences, Division of Ophthalmic Genetics

2005 - Present    Co-Director, Ophthalmology and Visual Sciences, Division of International Ophthalmology

2006-Present      Chair, resident research committee

2002 – Present    Member, Ophthalmology and Visual Sciences, Resident Selection Committee

2002 - Present    Member, Ophthalmology and Visual Sciences, Department Library Committee

2002 - Present    Member, Ophthalmology and Visual Sciences, Department Seminar Speaker Committee

Other Internal Level

2001 -2002         Member, Cleveland Clinic Foundation, Search Committee for the Director for the Center for Human Genetics and Genomics

1991 -1995         Member, Harvard University - M.I.T., M.D. Curriculum Committee, Division of Health Sciences and Technology

1988 -1989         President, Harvard University, Chinese Student Association

CURRENT MEMBERSHIPS IN PROFESSIONAL SOCIETIES

American Academy of Ophthalmology

American Association for the Advancement of Science

American Society for Clinical Investigation

American Society of Human Genetics

Association for Research in Vision and Ophthalmology

Macula Society

TEACHING RESPONSIBILITIES/ASSIGNMENTS
Course Lectures

2007-pres           Visiting Professor, Fudan University, China

2006-pres           Visiting Professor, Sichuan Academy of Medical Sciences, China

2005-pres           Frontiers in Neuroscience, PhD Program in Neuroscience, University of Utah, Salt Lake City, UT; contributing lecturer

2005                   Visiting Professor, King Khaled Eye Specialty Hospital. Riyahd, Saudi Arabia

2004                   Faculty Research Topic Lecture Series, PhD., Program in Molecular Biology, University of Utah, Salt Lake City, UT; Contributing lecturer

2003 - Present    Visiting Professor, Peking University Eye Center, Peking University, China

2003 - Present    Visiting Professor, Sichuan University, China

2003 - Present    Visiting Professor, Sichuan academy of Medical Sciences and Sichman Provincial Hospital, China

2003 - Present    Visiting Professor, Zhong Shan Ophthalmic Center, Sun Yet-sen University, China

2002 - Present    Fluorescein Angiogram Conference, John Moran Eye Center, University of Utah, Salt Lake City, UT; Contributing lecturer

2002 - Present    Grand Rounds, John Moran Eye Center, University of Utah, Salt Lake City, UT; Contributing lecturer

2002 - Present    Ophthalmology Resident Lectures - Lecture Series on the Retina, John Moran Eye Center, University of Utah, Salt Lake City, UT; Contributing lecturer

2000 -2002         Grand Rounds Quiz for residents, Cole Eye Institute, Cleveland Clinic

1992 -1994         Teaching Assistant in HMS-M.I.T. HST Genetics and Medicine, 80 students (MIT undergraduate and graduate students, Harvard Medical Students)

Students Supervised

2007-pres           Yuhong Chen, MD, PhD, Postdoctoral fellow

2006-pres           Haoyu Chen, MD, Postdoctoral fellow

2006-pres           Jessica Yang, MD, Postdoctoral fellow

2007-pres           Manjusha Dixie, PhD, Postdoctoral fellow

2007-pres           Ling Luo, MD, Postdoctoral fellow

2006-pres           Shrena Patel, MD, Postdoctoral fellow

2000 - Present    Zhenglin Yang, MD, Research Assistant Professor

2004 - present     Bradley Katz, MD, PhD. Post Doctoral Fellow, NIH K23 Mentored Clinician-Scientist Awardee, and Associate Professor

2004 - 2007        Josh Cameron, Neuroscience Program, University of Utah PhD Thesis Student

2007 – present    Ryan Constinine, Neuroscience Program, University of Utah PhD Thesis Student (MD/PhD)

2007 – present    Charity Olson, Molecular Biology Program, University of Utah PhD Thesis Student

2004 - 2006        Shin Kamaya, University of Utah Undergraduate Student

2005 - 2006        Asif Azimi, MD, Postdoctoral fellow

2005 - 2006        Jay Meyer, University of Utah Medical Student

2005 - 2006        Nathan Faulkner, University of Utah Medical Student

2005 - 2007        Rusten Gomez, University of Utah Undergraduate Student

2005 - 2007        Shan Duan, PhD, Postdoctoral fellow

2005 - 2006        Wendy Rao, University of Utah Undergraduate Student

2004                   Mac Machan, University of Utah Undergraduate Student

2004                   Nathan Faulkner, University of Utah Undergraduate Student

2004                   Parley Filmore, University of Illinois Medical Student

2004 - 2007        Yali Chen, PhD, Postdoctoral fellow

2004 - Present    Zongzhong Tong, PhD, Postdoctoral Fellow

2003                   Kristina Price, Emery University Medical Student

2003                   Marrielle Payne, University of Utah Medical Student

2003                   Yian Yin, University of Utah Medical Student

2003 -2005         Chunmei Li, MD, Postdoctoral fellow, Staff Physician, Zhongshan Ophthalmic center, China

2003 - 2005        Jianbin Hu, MD, Postdoctoral fellow

2002 - Present    Ophthalmology Attending. Supervising ophthalmology residents (PGY2-4), Moran Eye Center, Univ. of Utah

2002 - Present    Ophthalmology Attending. Supervising residents (PGY2-4) in retina and retina laser clinic, VA Hospital

2002 -2003         Jieyan Pan, PhD, Senior Postdoctoral fellow, University of Penn

2002 -2003         Keke Fan, PhD, Senior Postdoctoral fellow, Case Western University

2002 -2003         Lin Gan, MD, Senior Postdoctoral fellow, University of Heidelberg

2002 -2004         Li Jiang, MD, Postdoctoral Fellow/PhD Student,
Dept of Biology, University of Utah

2002 - 2007        Goutam Karan, PhD, Postdoctoral fellow

2001                   Wei Lin, Harvard Medical Student

2000 -2001         Zhengya Yu, M.D., Prior Postdoctoral student, Assoc. Prof. Surgery and Chief of Vascular Surgery, Tong Reng Eye Hospital, Beijing, China

2000 -2002         Ophthalmology Attending. Supervised residents (PGY3-4), Cole Eye Institute, Cleveland Clinic Foundation

2000 -2001         Zhengya Yu, MD, Postdoctoral Fellow, Assoc. Prof. Surgery and Chief of Vascular Surgery, Tong Reng Eye Hospital, Beijing, China

1999 -2000         Ophthalmology Attending. Supervised residents (PGY3-4), Wilmer Eye Institute, Johns Hopkins Hospital

1999 -2001         Yang Li, M.D., Prior Postdoctoral student, Assoc. Prof. Ophthalmology and Director of Research, Tong Reng Eye Hospital, Beijing, China

1999 -2001         Yang Li, MD, Postdoctoral Fellow, Assoc. Prof. Ophthalmology and Director of Research, Tong Reng Eye Hospital, Beijing, China

1993                   Edward Nugyen (Harvard College), UCSF Medical Student

1993                   Kristin Lictenberg (Wellesley College), Medical Student, University of Pittsburg Medical School

1992                   Howard Yeon (Harvard College), Harvard Medical Student

Continuing Education

CME Courses Taught

2005    Diabetic Retinopathy, Department of Public Health. Idaho State University, Boise, Idaho

2003    Clinical Faculty Day, John Moran Eye Center, University of Utah School of Medicine. Salt Lake City, Utah

Bibliography

ORIGINAL PUBLICATIONS
Peer-Reviewed Publications

1.      Kapler GM, Zhang K, Beverley SM. (1987) Sequence and S1 nuclease mapping of the 5' region of the dihydrofolate reductase-thymidylate synthase gene of Leishmania major. Nucleic Acids Res, 15(8), 3369-83.

2.      Kapler GM, Zhang K, Beverley SM. (1990) Nuclease mapping and DNA sequence analysis of transcripts from the dihydrofolate reductase-thymidylate synthase (R) region of Leishmania major. Nucleic Acids Res, 18(21), 6399-408.

3.      Perkins LA, Doctor JS, Zhang K, Stinson L, Perrimon N, Craig EA. (1990) Molecular and developmental characterization of the heat shock cognate 4 gene of Drosophila melanogaster. Mol Cell Biol, 10(6), 3232-8.

4.      Zhang K, Chaillet JR, Perkins LA, Halazonetis TD, Perrimon N. (1990) Drosophila homolog of the mammalian jun oncogene is expressed during embryonic development and activates transcription in mammalian cells. Proc Natl Acad Sci U S A, 87(16), 6281-5.

5.      Zhang K, Smouse D, Perrimon N. (1991) The crooked neck gene of Drosophila contains a motif found in a family of yeast cell cycle genes. Genes Dev, 5(6), 1080-91.

6.      Rutledge BJ*, Zhang K*, Bier E, Jan YN, Perrimon N. (1992) The Drosophila spitz gene encodes a putative EGF-like growth factor involved in dorsal-ventral axis formation and neurogenesis. Genes Dev, 6(8), 1503-17. co-first authors.

7.      Zhang K, Bither PP, Park R, Donoso LA, Seidman JG, Seidman CE. (1994) A dominant Stargardt's macular dystrophy locus maps to chromosome 13q34. Arch Ophthalmol, 112(6), 759-64.

8.      Hata Y, Duh E, Zhang K, Robinson GS, Aiello LP. (1998) Transcription factors Sp1 and Sp3 alter vascular endothelial growth factor receptor expression through a novel recognition sequence. J Biol Chem, 273(30), 19294-303.

9.      Kniazeva M, Chiang MF, Morgan B, Anduze AL, Zack DJ, Han M, Zhang K. (1999) A new locus for autosomal dominant stargardt-like disease maps to chromosome 4. Am J Hum Genet, 64(5), 1394-9.

10. Kniazeva MF, Chiang MF, Cutting GR, Zack DJ, Han M, Zhang K. (1999) Clinical and genetic studies of an autosomal dominant cone-rod dystrophy with features of Stargardt disease. Ophthalmic Genet, 20(2), 71-81.

11. Zhang K, Garibaldi DC, Kniazeva M, Albini T, Chiang MF, Kerrigan M, Sunness JS, Han M, Allikmets R. (1999) A novel mutation in the ABCR gene in four patients with autosomal recessive Stargardt disease. Am J Ophthalmol, 128(6), 720-4.

12. Zhang K, Jampel HD. (1999) Discordance of primary infantile glaucoma in monozygotic twins. Am J Ophthalmol, 128(1), 97-8.

13. Zhang K, Kniazeva M, Hutchinson A, Han M, Dean M, Allikmets R. (1999) The ABCR gene in recessive and dominant Stargardt diseases: a genetic pathway in macular degeneration. Genomics, 60(2), 234-7.

14. Allikmets R. (2000) Further evidence for an association of ABCR alleles with age-related macular degeneration. The International ABCR Screening Consortium. Am J Hum Genet, 67(2), 487-91.

15. Kniazeva M, Traboulsi EI, Yu Z, Stefko ST, Gorin MB, Shugart YY, O'Connell JR, Blaschak CJ, Cutting G, Han M, Zhang K. (2000) A new locus for dominant drusen and macular degeneration maps to chromosome 6q14. Am J Ophthalmol, 130(2), 197-202.

16. Stefko ST, Zhang K, Gorin MB, Traboulsi EI. (2000) Clinical spectrum of chromosome 6-linked autosomal dominant drusen and macular degeneration. Am J Ophthalmol, 130(2), 203-8.

17. Ayyagari R, Zhang K, Hutchinson A, Yu Z, Swaroop A, Kakuk LE, Seddon JM, Bernstein PS, Lewis RA, Tammur J, Yang Z, Li Y, Zhang H, Yashar BM, Liu J, Petrukhin K, Sieving PA, Allikmets R. (2001) Evaluation of the ELOVL4 gene in patients with age-related macular degeneration. Ophthalmic Genet, 22(4), 233-9.

18. Bernstein PS, Tammur J, Singh N, Hutchinson A, Dixon M, Pappas CM, Zabriskie NA, Zhang K, Petrukhin K, Leppert M, Allikmets R. (2001) Diverse macular dystrophy phenotype caused by a novel complex mutation in the ELOVL4 gene. Invest Ophthalmol Vis Sci, 42(13), 3331-6.

19. Li Y, Marcos I, Borrego S, Yu Z, Zhang K, Antinolo G. (2001) Evaluation of the ELOVL4 gene in families with retinitis pigmentosa linked to the RP25 locus. J Med Genet, 38(7), 478-80.

20. Wilkie SE, Li Y, Deery EC, Newbold RJ, Garibaldi D, Bateman JB, Zhang H, Lin W, Zack DJ, Bhattacharya SS, Warren MJ, Hunt DM, Zhang K. (2001) Identification and functional consequences of a new mutation (E155G) in the gene for GCAP1 that causes autosomal dominant cone dystrophy. Am J Hum Genet, 69(3), 471-80.

21. Zhang K, Kniazeva M, Han M, Li W, Yu Z, Yang Z, Li Y, Metzker ML, Allikmets R, Zack DJ, Kakuk LE, Lagali PS, Wong PW, MacDonald IM, Sieving PA, Figueroa DJ, Austin CP, Gould RJ, Ayyagari R, Petrukhin K. (2001) A 5-bp deletion in ELOVL4 is associated with two related forms of autosomal dominant macular dystrophy. Nature Genet, 27(1), 89-93.

22. Yang Z, Peachey NS, Moshfeghi DM, Thirumalaichary S, Chorich L, Shugart YY, Fan K, Zhang K. (2002) Mutations in the RPGR gene cause X-linked cone dystrophy. Hum Mol Genet, 11(5), 605-11.

23. Zhang K, Garibaldi DC, Li Y, Green WR, Zack DJ. (2002) Butterfly-shaped pattern dystrophy: a genetic, clinical, and histopathological report. Arch Ophthalmol, 120(4), 485-90.

24. Johnson S, Halford S, Morris AG, Patel RJ, Wilkie SE, Hardcastle AJ, Moore AT, Zhang K, Hunt DM. (2003) Genomic organisation and alternative splicing of human RIM1, a gene implicated in autosomal dominant cone-rod dystrophy (CORD7). Genomics, 81(3), 304-14.

25. Kniazeva M, Sieber M, McCauley S, Zhang K, Watts JL, Han M. (2003) Suppression of the ELO-2 FA elongation activity results in alterations of the fatty acid composition and multiple physiological defects, including abnormal ultradian rhythms, in Caenorhabditis elegans. Genetics, 163(1), 159-69.

26. Yang Z, Lin W, Moshfeghi DM, Thirumalaichary S, Li X, Jiang L, Zhang H, Zhang S, Kaiser PK, Traboulsi EI, Zhang K. (2003) A novel mutation in the RDS/Peripherin gene causes adult-onset foveomacular dystrophy. Am J Ophthalmol, 135(2), 213-8.

27. Zhang XM, Yang Z, Karan G, Hashimoto T, Baehr W, Yang XJ, Zhang K. (2003) Elovl4 mRNA distribution in the developing mouse retina and phylogenetic conservation of Elovl4 genes. Mol Vis, 9301-7.

28. Berry V, Yang Z, Addison PK, Francis PJ, Ionides A, Karan G, Jiang L, Lin W, Hu J, Yang R, Moore A, Zhang K, Bhattacharya SS. (2004) Recurrent 17 bp duplication in PITX3 is primarily associated with posterior polar cataract (CPP4). J Med Genet, 41(8), e109.

29. Hunt DM, Wilkie SE, Newbold R, Deery E, Warren MJ, Bhattacharya SS, Zhang K. (2004) Dominant cone and cone-rod dystrophies: functional analysis of mutations in retGC1 and GCAP1. Novartis Found Symp, 25537-49; discussion 49-50, 177-8.

30. Karan G, Yang Z, Zhang K. (2004) Expression of wild type and mutant ELOVL4 in cell culture: subcellular localization and cell viability. Mol Vis, 10248-53.

31. Maugeri A, Meire F, Hoyng CB, Vink C, Van Regemorter N, Karan G, Yang Z, Cremers FP, Zhang K. (2004) A novel mutation in the ELOVL4 gene causes autosomal dominant Stargardt-like macular dystrophy. Invest Ophthalmol Vis Sci, 45(12), 4263-7.

32. Payne M, Yang Z, Katz BJ, Warner JE, Weight CJ, Zhao Y, Pearson ED, Treft RL, Hillman T, Kennedy RJ, Meire FM, Zhang K. (2004) Dominant optic atrophy, sensorineural hearing loss, ptosis, and ophthalmoplegia: a syndrome caused by a missense mutation in OPA1. Am J Ophthalmol, 138(5), 749-55.

33. Toomes C, Bottomley HM, Jackson RM, Towns KV, Scott S, Mackey DA, Craig JE, Jiang L, Yang Z, Trembath R, Woodruff G, Gregory-Evans CY, Gregory-Evans K, Parker MJ, Black GC, Downey LM, Zhang K, Inglehearn CF. (2004) Mutations in LRP5 or FZD4 underlie the common familial exudative vitreoretinopathy locus on chromosome 11q. Am J Hum Genet, 74(4), 721-30.

34. Toomes C, Bottomley HM, Scott S, Mackey DA, Craig JE, Appukuttan B, Stout JT, Flaxel CJ, Zhang K, Black GC, Fryer A, Downey LM, Inglehearn CF. (2004) Spectrum and frequency of FZD4 mutations in familial exudative vitreoretinopathy. Invest Ophthalmol Vis Sci, 45(7), 2083-90.

35. Xu Q, Wang Y, Dabdoub A, Smallwood PM, Williams J, Woods C, Kelley MW, Jiang L, Tasman W, Zhang K, Nathans J. (2004) Vascular development in the retina and inner ear: control by Norrin and Frizzled-4, a high-affinity ligand-receptor pair. Cell, 116(6), 883-95.

36. Yang Z, Li Y, Jiang L, Karan G, Moshfeghi D, O'Connor S, Li X, Yu Z, Lewis H, Zack D, Jacobson S, Zhang K. (2004) A novel RDS/peripherin gene mutation associated with diverse macular phenotypes. Ophthalmic Genet, 25(2), 133-45.

37. Berthelemy-Okazaki N, Zhao Y, Yang Z, Camp NJ, Farnham J, Parker D, Tsuruda J, Macdonald J, Zhang K, Cannon-Albright LA. (2005) Examination of ELN as a candidate gene in the Utah intracranial aneurysm pedigrees. Stroke, 36(6), 1283-4.

38. Jiang L, Katz BJ, Yang Z, Zhao Y, Faulkner N, Hu J, Baird J, Baehr W, Creel DJ, Zhang K. (2005) Autosomal dominant cone dystrophy caused by a novel mutation in the GCAP1 gene (GUCA1A). Mol Vis, 11143-51.

39. Karan G, Lillo C, Yang Z, Cameron DJ, Locke KG, Zhao Y, Thirumalaichary S, Li C, Birch DG, Vollmer-Snarr HR, Williams DS, Zhang K. (2005) Lipofuscin accumulation, abnormal electrophysiology, and photoreceptor degeneration in mutant ELOVL4 transgenic mice: a model for macular degeneration. Proc Natl Acad Sci U S A, 102(11), 4164-9.

40. Karan G, Yang Z, Howes K, Zhao Y, Chen Y, Cameron DJ, Lin Y, Pearson E, Zhang K. (2005) Loss of ER retention and sequestration of the wild-type ELOVL4 by Stargardt disease dominant negative mutants. Mol Vis, 11657-64.

41. Li C, Kosmorsky G, Zhang K, Katz BJ, Ge J, Traboulsi EI. (2005) Optic atrophy and sensorineural hearing loss in a family caused by an R445H OPA1 mutation. Am J Med Genet A, 138(3), 208-11.

42. Pauer GJ, Xi Q, Zhang K, Traboulsi EI, Hagstrom SA. (2005) Mutation screen of the membrane-type frizzled-related protein (MFRP) gene in patients with inherited retinal degenerations. Ophthalmic Genet, 26(4), 157-61.

43. Yang Z, Alvarez BV, Chakarova C, Jiang L, Karan G, Frederick JM, Zhao Y, Sauve Y, Li X, Zrenner E, Wissinger B, Hollander AI, Katz B, Baehr W, Cremers FP, Casey JR, Bhattacharya SS, Zhang K. (2005) Mutant carbonic anhydrase 4 impairs pH regulation and causes retinal photoreceptor degeneration. Hum Mol Genet, 14(2), 255-65.

44. Bidinost C, Matsumoto M, Chung D, Salem N, Zhang K, Stockton DW, Khoury A, Megarbane A, Bejjani BA, Traboulsi EI. (2006) Heterozygous and homozygous mutations in PITX3 in a large Lebanese family with posterior polar cataracts and neurodevelopmental abnormalities. Invest Ophthalmol Vis Sci, 47(4), 1274-80.

45. Chen H, Chen Y, Horn R, Yang Z, Wang C, Turner MJ, Zhang K. (2006) Clinical features of autosomal dominant retinitis pigmentosa associated with a Rhodopsin mutation. Ann Acad Med Singapore, 35(6), 411-5.

46. Katz BJ, Yang Z, Payne M, Lin Y, Zhao Y, Pearson E, Duan S, Kamaya S, Karan G, Zhang K. (2006) Fundus appearance of choroideremia using optical coherence tomograpy. Adv Exp Med Biol, 57257-61.

47. Katz BJ, Zhang K. (2006) Juxtapapillary hemangioblastoma as a manifestation of von Hippel-Lindau disease. Pediatr Int, 48(4), 423-5.

48. Katz BJ, Zhao Y, Warner JE, Tong Z, Yang Z, Zhang K. (2006) A family with X-linked optic atrophy linked to the OPA2 locus Xp11.4-Xp11.2. Am J Med Genet A, 140(20), 2207-11.

49. Li Y, Wang G, Dong B, Sun X, Turner MJ, Kamaya S, Zhang K. (2006) A novel mutation of the VMD2 gene in a Chinese family with best vitelliform macular dystrophy. Ann Acad Med Singapore, 35(6), 408-10.

50. Magnusson KP*, Duan S, Sigurdsson H, Petursson H, Yang Z, Zhao Y, Bernstein PS, Ge J, Jonasson F, Stefansson E, Helgadottir G, Zabriskie NA, Jonsson T, Bjornsson A, Thorlacius T, Jonsson PV, Thorleifsson G, Kong A, Stefansson H, Zhang K*, Stefansson K, Gulcher JR*. (2006) CFH Y402H confers similar risk of soft drusen and both forms of advanced AMD. PLoS Med, 3(1), 109-114. *Co-corresponding authors.

51. Nozaki M, Raisler BJ, Sakurai E, Sarma JV, Barnum SR, Lambris JD, Chen Y, Zhang K, Ambati BK, Baffi JZ, Ambati J. (2006) Drusen complement components C3a and C5a promote choroidal neovascularization. Proc Natl Acad Sci U S A, 103(7), 2328-33.

52. Sauve Y, Karan G, Yang Z, Li C, Hu J, Zhang K. (2006) Treatment with carbonic anhydrase inhibitors depresses electroretinogram responsiveness in mice. Adv Exp Med Biol, 572439-46.

53. Tong Z, Yang Z, Meyer JJ, McInnes AW, Xue L, Azimi AM, Baird J, Zhao Y, Pearson E, Wang C, Chen Y, Zhang K. (2006) A novel locus for X-linked retinitis pigmentosa. Ann Acad Med Singapore, 35(7), 476-8.

54. Wang C, Hu J, Bernstein PS, Teske MP, Payne M, Yang Z, Li C, Adams D, Baird JH, Zhang K. (2006) Intravitreal injection of triamcinolone acetonide for macular edema due to retinitis pigmentosa and other retinal diseases. Adv Exp Med Biol, 572309-14.

55. Wang C, Katz BJ, Turner MJ, Hu J, Zhang K. (2006) Intravitreal triamcinolone acetonide for the treatment of diffuse diabetic macular oedema--a case report. Ann Acad Med Singapore, 35(2), 112-4.

56. Brown DM, Kaiser PK, Michels M, Goubrane MD, Heier, JS, Kim RY, Sy JP, Schneider S for the ANCHOR Study Group. (2006) Ranibizumab versus Vertiporfin for Neovascular Age-Related Macular Degeneration. New Eng J of Med, 355 (14) 1432-1444.

57. Rosenfeld PJ, Brown DM, Heier JS, Boyer DS, Kaiser PK, Chung CY, Kim RY for the MARINA Study Group. (2006) Ranibizumab for Neovascular Age-Related Macular Degeneration, New Eng J of Med, 355 (14) 1419-1431.

58. Yang Z, Camp NJ, Sun H, Tong Z, Gibbs D, Cameron DJ, Chen H, Zhao Y, Pearson E, Li X, Chien J, Dewan A, Harmon J, Bernstein PS, Shridhar V, Zabriskie NA, Hoh J, Howes K, Zhang K. (2006) A variant of the HTRA1 gene increases susceptibility to age-related macular degeneration. Science, 314(5801), 992-3.

59. Alvarez BV, Vithana EN, Yang Z, Koh AH, Yeung K, Yong V, Shandro HJ, Chen Y, Kolatkar P, Palasingam P, Zhang K, Aung T, Casey JR. (2007) Identification and characterization of a novel mutation in the carbonic anhydrase IV gene that causes retinitis pigmentosa. Invest Ophthalmol Vis Sci, 48(8), 3459-68.

60. Cameron DJ, Tong Z, Yang Z, Kaminoh J, Kamiyah S, Chen H, Zeng J, Chen Y, Luo L, Zhang K. (2007) Essential role of Elovl4 in very long chain fatty acid synthesis, skin permeability barrier function, and neonatal survival. Int J Biol Sci, 3(2), 111-9.

61. Cameron DJ, Yang Z, Gibbs D, Chen H, Kaminoh Y, Jorgensen A, Zeng J, Luo L, Brinton E, Brinton G, Brand JM, Bernstein PS, Zabriskie NA, Tang S, Constantine R, Tong Z, Zhang K. (2007) HTRA1 Variant Confers Similar Risks to Geographic Atrophy and Neovascular Age-related Macular Degeneration. Cell Cycle, 6(9), 1122-5.

62.   Fu L, Garland D, Yang Z, Shukla D, Rajendran A, Pearson E, Stone EM, Zhang K, Pierce EA. (2007) The R345W Mutation in EFEMP1 is Pathogenic, and Causes AMD-Like Deposits in Mice. Hum Mol Genet. 16, 3411-22.

63. Li W, Chen Y, Cameron DJ, Wang C, Karan G, Yang Z, Zhao Y, Pearson E, Chen H, Deng C, Howes K, Zhang K. (2007) Elovl4 haploinsufficiency does not induce early onset retinal degeneration in mice. Vision Res, 47(5), 714-22.

64. Tuo J, Bojanowski CM, Zhou M, Shen D, Ross RJ, Rosenberg KI, Cameron DJ, Yin C, Kowalak JA, Zhuang Z, Zhang K, Chan CC. (2007) Murine ccl2/cx3cr1 deficiency results in retinal lesions mimicking human age-related macular degeneration. Invest Ophthalmol Vis Sci, 48(8), 3827-36.

65. Yu J, Wiita P, Kawaguchi R, Honda J, Jorgensen A, Zhang K, Fischetti VA, Sun H. (2007) Biochemical analysis of a common human polymorphism associated with age-related macular degeneration. Biochemistry, 46(28), 8451-61.

66. Kaiser PK, Brown DM, Zhang K, Hudson HL, Holz FG, Shapiro H, Schneider S, Acharya NR (2007). Ranibizumab for Predominantly Classic Neovascular Age-related Macular Degeneration: Subgroup Analysis of First-year ANCHOR Results. Am J Ophthalmol. 2007 Oct 17; [Epub ahead of print].

67. Chen H, Yang Z, Gibbs D, Yang X, Hau V, Zhao P, Ma X, Zeng J, Luo L, Pearson E, Constantine R, Kaminoh Y, Harmon J, Tong Z, Stratton CA, Cameron JD, Tang S, Zhang, K. Association of HTRA1 polymorphism and bilaterality in advanced age related macular degeneration. Vision Research, in press.

68. Gibbs D, Yang Z, Constantine R, Cameron J, Chen H, DeWan A, Ma X, Yang X, Jorgenson A, Zeng J, Harmon J, Tong Z, Hoh J, Zhang K. Further mapping of 10q26 supports strong association of an HTRA1 promoter polymorphism as a causal variant in age-related macular degeneration. Vision Research, in press

69. Lu F, Hu J, Zhao, P, Lin Y, Yang Y, Liu X, Fan Y, Chen B, Liao S, Du, Q, Lei C, Cameron J, Zhang K*, Yang Z*. HTRA1 variant increases risk to neovascular age-related macular degeneration in Chinese population. (2007) Vision Research 2007 Nov; 47(24):3120-3123. Epub 2007 Sep 27. *co-corresponding authors.

70. Yang Z, Tong Z, Chorich LJ, Pearson E, Moore A, Hunt DM, Zhang K. (2007) Clinical feature and fine mapping of North Caronila Macular Degeneration Vision Research in press .

71. Ma, X, Zabriskie, NA, Hau, VS, Chen, H, Tong, Z, Yang, X, Gibbs, D, Katz, BJ, Luo, , Pearson, E, Goldsmith, J, Kaminoh, Y, Zeng, J, Zhang K*, and Yang, Z*. Genetic association of LOXL1 gene variants and exfoliation glaucoma in a Utah cohort. Cell Cycle, in press. *co-corresponding authors.

72. Kleiman M E, Yamada K, Kakeda A, Chandrasekaran V, Nozaki M, Baffi J Z, Albuquerque R J C, Yamasake S, Itaya M, Pan Y, Appukuttan B, Gibbs D, Yang Z, Kariko K, Ambati B, Wilgus T A, DiPietro L A, Sakurai E, Zhang K, Smith T R, Taylor E W, Ambati J. (2008). Sequence- and target-independent suppression of angiogenesis by siRNA via TLR3. Nature 452, 591-597.

73. Jones, CA, London, NR., Chen, H, Park, KW., Sauvaget, D., Rebecca A. Stockton, RA., Wythe, J. D., Suh, W., Larrieu-Lahargue, F., Mukouyama, Y., Lindblom, P., Seth, P., Frias, A., Nishiya, N., Ginsberg, M., Gerhardt, H, Zhang, K.*, and Li, D.Y.* (2008). Robo4 stabilizes the vascular network by inhibiting pathologic angiogenesis and endothelial hyperpermeability. Nature Medicine 14, 448-453. *co-corresponding authors.

74. Tong Z, Yang Z, Patel S, Chen H, Gibbs D, Zeng J, Yang X, Ma X, Harmon J, Pearson E, Beuhler J, Luo L, Hau VS, Kaminoh Y, Zabriskie NA, Sun JK, Prakash M, Haman R, Tonna S, Constantine R, Ronquillo CC, Sadda SV, Avery RL, Brand JM, London N, King GL, Bernstein PS, Watkins S, Genetics of Diabetes and Diabetic Complication Study Group, Jorde LB, Li DY, Aiello LP, Pollak MR, Zhang K. Promoter polymorphism of the Erythropoietin gene in severe diabetic eye and kidney complications. Proc Natl Acad Sci, 2008; in press.

B.     Non Peer-Reviewed Publications

1.   Hunt DM, Wilkie SE, Newbold R, Deery E, Warren MJ, Bhattacharya SS, Zhang K. (2004). Dominant cone and cone-rod dystrophies: functional analysis of mutations in retGC1 and GCAP1. Novartis Found Symp, 255, 37-49; discussion 49-50, 177-8.

REVIEW ARTICLES

1.      Patel, S, Chen H, Tinkham, NH, Zhang, K, (2008). Genetic susceptibility of Diabetic retinopathy. Current Diabetic Report, 8, in press

2.      Garibaldi D, Zhang K. (1999). Molecular genetics of macular degeneration. Intl Ophthal. Clinics, 39, 117.

3.      Zhang K, Yeon H, Han M, Donoso LA. (1996). Molecular genetics of macular dystrophies. Br J Ophthalmol, 80(11), 1018-22.

4.      Zhang K, Nguyen E, Crandall A, Donoso LA. (1995). Genetic and molecular studies of macular dystrophies: recent development. Survey of Ophthalmology, 40, 51.

5.      Zhang K, Wang MX, Munier F, Roth D, Mastrangelo D, Chung S, Shields JA, Donoso LA. (1993). Molecular genetics of retinoblastoma. Int Ophthalmol Clin, 33(3), 53-65.

BOOK CHAPTERS

1.      Cameron DJ, Yang Z, Tong Z, Zhao Y, Praggastis A, Brinton E, Harmon J, Chen Y, Pearson E, Bernstein PS, Brinton G, Li X, Jorgensen A, Schneider S, Gibbs D, Chen H, Wang C, Howes K, Camp NJ, Zhang K. (2008) 10q26 is associated with increased risk of age-related macular degeneration in the Utah population. In Anderson RE, LaVail MM, Hollyfield JG (Eds.), Recent Advances In Retinal Degeneration. New York: Plenum Publishing Corporation.

2.      Chen H, Yang Z, Zhao P, Zhang K (2008). Genetics of AMD. in Kaiser PK, Sears J, Singh R (Eds), Macular Degeneration – State of the Art. London, Remedica Medical Education and Publishing Limited (in press)

3.      Moshfeghi DM, Yang Z, Faulkner ND, Karan G, Hirumalaichary S, Jiang L, Tsai T, Zhang K. (2005). Choroidal Neovascularization in Patients with Adult-onset Foveomacular Dystrophy Caused by Mutations in the RDS/Peripherin Gene: Report of 3 Cases. In Hollyfield JG, Anderson RE, LaVail MM (Eds.), Retinal Degeneration: Clinical and Laboratory Applications. New York: Plenum Publishing Corporation.

4.      Katz BJ, Yang Z, Payne M, Zhang K. (2005). Fundus Appearance of Choroideremia. In Hollyfield JG, Anderson RE, LaVail MM (Eds.), Retinal Degeneration: Clinical and Laboratory Applications. New York: Plenum Publishing Corporation.

5.      Zhang K, Carr RE, Sunness JS. (2005). Hereditary chorodial dystrophies. In Ryan SJ (Ed.), Retina.

6.      Hu J, Payne M, Zhang K. (2005). Intravitreal Injection of Triamcinolone Acetonide for Macular Edema Due to Retinitis Pigmentosa and Other Retinal Diseases. In Hollyfield JG, Anderson RE, LaVail MM (Eds.), Retinal Degeneration: Clinical and Laboratory Applications. New York: Plenum Publishing Corporation.