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Kang Zhang, MD, PhD
Curriculum Vitae

  1. PERSONAL DATA

Name: Kang Zhang
Birth Place: China
Citizenship: United States

  1. EDUCATION
    1. Baccalaureate Degree

1980 - 1984   BS, Sichuan University, Sichuan, Chengdu, Biochemistry

    1. Advanced Degree

1991 - 1995   MD, Harvard University Medical School - M.I.T., Cambridge, MA, Medicine
1985 - 1991   PhD, Harvard University, Cambridge, MA, Genetics

    1. Resident/Fellowship Training

2002 - 2003   FELLOW, University of Utah School of Medicine, Salt Lake City, UT, Retina
1996 - 1999   RESIDENT, Johns Hopkins University, Wilmer Eye Institute, Baltimore, MD, Ophthalmology
1995 - 1996   INTERN, Presbyterian/St. Lukes Hospital, Denver, CO, Medicine

    1. Postdoctoral Fellowship

1996 - 1999   Johns Hopkins University, Wilmer Eye Institute, Baltimore, MD. Ophthalmology
1992 - 1995   Harvard Medical School, HHMI, Cambridge, MA. Genetics

  1. BOARD CERTIFICATIONS

Am Bd Ophthalmology (Ophthal), 05/13/2001, Certified
National Bd Medical Examiners, 01/01/1996, Certified

  1. CURRENT LICENSES/CERTIFICATIONS

State License (UT) 2005-2008
CS (UT) 2005-2008
DEA Certificate (UT) 2004-2007
State License (OH) 2000-2007
State License (MD) 1999-2007

  1. ACADEMIC HISTORY

Neurobiology and Anatomy
Hire, Adjunct Track, Adjunct Assistant Professor, 01/01/2004
Ophthalmology/Visual Sciences
Hire, Tenure Track-Scientist Scholar, Assistant Professor, 03/01/2002
Promotion, Associate Professor, 07/01/2006
Tenure, 07/01/2006

  1. PROFESSIONAL EXPERIENCE
    1. Full Time Positions

2006 – Present  Associate Professor, University of Utah, Department of Ophthalmology and Visual Science, John Moran Eye Center, Salt Lake City, UT
2002 - Present Investigator, University of Utah, Eccles Institute of Human Genetics, Program in Human Molecular Biology & Genetics, Salt Lake City, UT
2002 - Present Attending Staff Physician, Veteran's Administration Medical Center, Salt Lake City, UT
2002 -2006        Assistant Professor, University of Utah, Department of Ophthalmology and Visual Science, John Moran Eye Center, Salt Lake City, UT
2000 -2002        Assistant Professor, Cleveland Clinic Foundation, Cole Eye Institute, Cleveland, OH
1999 -2000        Instructor, Johns Hopkins University, School of Medicine, Wilmer Eye Institute, Baltimore, MD
1999 -2000        Attending Physician, Johns Hopkins Hospital, Baltimore, MD

    1. Editorial Experience

2001     Guest, Editorial Board for Investigative Ophthalmology and Visual Science

    1. Reviewer Experience

Referee for American Journal of Human Genetics
Referee for American Journal of Medical Genetics
Referee for Archives of Ophthalmology
Referee for Biochemical Journal
Referee for BMC Genomics
Referee for Developmental Dynamics
Referee for Human Genetics
Referee for Human Molecular Genetics
Referee for International Journal of Biologic Science
Referee for Investigative Ophthalmology and Visual Science
Referee for Journal of Biological Chemistry
Referee for Journal of Cataract and Refractive Surgery
Referee for Journal of Medical Genetics
Referee for Journal of Neurology
Referee for Molecular Vision
Referee for Nature Genetics
Referee for Ophthalmic Genetics
Referee for Ophthalmology
Referee for PNAS
Referee for PLoS Biology
Referee for PLoS Medicine
Referee for PLoS One
Referee for Progress in Retina and Eye Research
Referee for Retina
Referee for Trend in Genetics

  1. RESEARCH AWARDS
    1. Contracts

VEGF Phase III Clinical Trial for predominantly classic choroidal neovasculariation of age-related macular degeneration (ANCHOR).  06/01/2003 - 12/31/2005.  Genentech Inc,  Direct Costs: $633,694. Total costs: $788,160.  Principal Investigator.
VEGF Phase III Clinical Trial for minimally classic and completely occult choroidal neovasculariation of age-related macular degeneration (MARINA).  08/01/2003 - 03/31/2006.  Genentech Inc,  Direct Costs: $686,082. Total costs: $838,321.  Principal Investigator.
University of Utah PI for a multi-center study of an anti-VEGF aptamer for choroidal neovascularization from age-related macular degeneration sponsored by EyeTech pharmaceuticals and Pfizer  07/01/2001 - 07/31/2004.  Eyetech Pharmaceuticals, Inc.,  Direct Costs: $142,647. Total costs: $180,271.  Co-Investigator.
A Multicenter, Randomized, Double-Masked, Controlled Study to Evaluate Intravitreal Fluocinolone Acetonide (.5, 2, or 6 mg) Implant in Patients with Non-Infectious Uveitis Affecting the Posterior Segment of the Eye. BLP 415-001  02/01/2001 - 02/28/2005.  Bausch & Lomb,  Direct Costs: $164,165. Total costs: $195,498.  Co-Investigator.
Open-Label, Multicenter Extension Study to Evaluate the Safety and Tolerability of Ranibizumab in Subjects with CNV Secondary to AMD who have Completed the Treatment Phase of a Genentech-Sponsored Ranibizumab Study.  09/01/2005 - present.  Genentech Inc,  Direct Costs: $100,500. Total costs: $100,500.  Principal Investigator.
An open-label, multicenter extension study to evaluate the safety and tolerability of ranibizumab in subjects with choroidal neovascularization (CNV) secondary to age-related macular degeneration (AMD) who have completed the treatment phase of III Anchor or Marina trials.
09/01/2005 - present.  Genentech Inc,  Direct Costs: $100,500.   Principal Investigator.
A Six-Month, Phase III, Multicentered, Masked, Randomized, Sham-Controlled Trial (With Six-Month Open Label Extension) To Assess the Safety and Efficacy of 700 microgram and 350 microgram Dexamethasone Posterior Segment Drug Delivery System (DEX PSDDS) Applicator System in the Treatment of Patients with Macular Edema Following Central Retinal Vein Occlusion or Branch Retinal Vein Occlusion.  04/01/2002 - .  Allergan Inc, Co-Investigator.
An Evaluation of Efficacy and Safety of Posterior Juxtascleral Injections of Anecortative Acetate (15 mm) vs. Visudyne Patients with Subfoveal Exudative Age-Related Macular Degeneration (AMD).  04/01/2002 - 03/31/2006.  Alcon Laboratories, Co-Investigator.
A Phase II Study of Implants of Encapsulated Human NTC-201 Cells Releasing Ciliary Neurotrophic Factor (CNTF), in Participants with Visual Acuity Impairment Associated with Atrophic Macular Degeneration (CNTF2).  Neurotech.  Principal Investigator.
Phase II/III Study of Encapsulated Human NTC-201 Cell Implants Releasing Ciliary Neurotrophic Factor (CNTF) for Participants with Retinitis Pigmentosa Using Visual Acuity as the Primary Outcome (CNTF3). Neurotech.  Principal Investigator.
Phase II/III Study of Encapsulated Human NTC-201 Cell Implants Releasing Ciliary Neurotrophic Factor (CNTF) for Participants with Retinitis Pigmentosa Using Visual Field Sensitivity as the Primary Outcome. Neurotech.  Principal Investigator.
VEGF and HTRA1 DNA polymorphisms in neovascular AMD pathogenesis and response to Lucentis
Genentech. Direct Costs: $500,500.   Principal Investigator.

    1. Grants

Genetics of diabetic nephropathy and retinopathy  10/01/2007 - 09/30/2010.  National Institute of Diabetes & Digestive & Kidney Diseases, Principal Investigator. Status: Pending.

ELOVL4 and Retinal Disease. R01 EY014428  05/01/2002 - 04/30/2012.  National Eye Institute,  Direct Costs: $250,000 per year. Total costs: $375,000 per year.  Principal Investigator. .

Wynn Center for the Study of Retinal Degeneration (Baehr)
 07/01/2005 - 06/30/2010.  Foundation Fighting Blindness,  Direct Costs: $45,000 per year. Total costs: $45,000 per year.  Module II:  Molecular genetics.  Principal Investigator.

Gene Identification for Age-Related Macular Degeneration.  07/01/2005 - 06/30/2008.  Knights Templar Eye Research Grant for Lejin Wang: Genetic Linkage Mapping of Leber's Congenital Amaurosis.  06/01/2005 - 06/30/2006.  Knight's Templar Eye Foundation,  Direct Costs: $30,000. Total costs: $30,000.  Principal Investigator.

Fellowship for Nathan Faulkner: Genetic Linkage Study of a Family with Marfan Syndrome.  05/01/2005 - 09/30/2005.  Fight for Sight, Inc.,  Direct Costs: $2,100. Total costs: $2,100.  Principal Investigator.
 

Pharmacological intervention of retinal degeenration in ELOVL4 transgenic mice to assess drugs for retinal degeneration intervention. FR-PT-0505-0237  01/01/2005 - 12/31/2006.  Foundation Fighting Blindness,  Direct Costs: $119,000. Total costs: $119,000.  Principal Investigator.
 
Genetics of Macular Degeneration - To clone and characterize the disease gene for North Carolina macular dystrophy.  RO1EY16698.  11/30/2003 - 07/30/2008.  National Eye Institute, Direct Costs: $385,000 per year. Total costs: $580,000 per year.  Principal Investigator.

Gene Identification for Juvenile Retinal Dystrophy.  11/01/2003 - 10/31/2006.  Ronald McDonald House Charities,  Direct Costs: $80,000 per year. Total costs: $80,000 per year.  Principal Investigator.

Gene Mapping for Stargardt's Macular Degeneration.  04/01/2002 - 03/31/2003.  American Health Assistance Foundation,  Direct Costs: $50,000. Total costs: $50,000.  Principal Investigator.

Macular Degeneration Genetics. 49580-001.45  04/01/2002 - 03/31/2004.  Karl Kirchgessner Foundation,  Direct Costs: $50,000; Total costs: $50,000.  Principal Investigator.
Gene Identification for Macular Degeneration.  04/01/2002 - 07/31/2005.  Ruth and Milton Steinbach Fund, Direct Costs: $300,000. Total costs: $300,000.  Principal Investigator.

Mentored Clinician Scientist Award K23EY00401. Project: "Cloning a gene for dominant Stargardt's disease"; Goal: to clone a gene for dominant Stargardt's disease.
  08/01/1999 - 07/30/2004.  National Eye Institute,  Direct Costs: $175,000 per year. Total costs: $210,000.  Principal Investigator.

Eye Research Award  01/01/1996 - 12/31/1996.  Knight's Templar Eye Foundation,  Direct Costs: $30,000. Total costs: $30,000.  Principal Investigator.

  1. SCHOLASTIC HONORS

Lew R. Wasserman Merit Award, Research to Prevent Blindness, 2006
Macula Society membership, 2006
American Society of Clinical Investigation membership, 2006
Charles Schepens Award for Excellence in Retina Research. 2001
Johns Hopkins Medical Institutions Clinician Scientist Award. 1999
Stark Research Award in Ophthalmology, Wilmer Eye Institute, Johns Hopkins University. 1998
Association of University Professors of Ophthalmology (AUPO) Inaugural Residents and Fellow's Research Forum, runner-up. 1997
Knights Templar Eye Foundation Research Award. 1996
Magna Cum Laude, Harvard Medical School. 1995
First Bower Award for Research on Macular Degeneration, Wills Eye Hospital, Philadelphia. 1993
Reed Scholar, M.I.T.. 1993 -1994
Johnson & Johnson Scholar, M.I.T.. 1991 -1992
Chinese National Scholarship for Graduate Studies Abroad. 1984
Highest Scholarships and High Distinction in Biochemistry, Sichuan Univ. 1980 -1984

  1. ADMINISTRATIVE EXPERIENCE
    1. Grant Review Committee/Study Section

2006                             Ad Hoc Reviewer, Anterior Eye Disease Study Section (VISA), NIH
2006-Present    Ad Hoc Reviewer, research grants, Wellcome Trust, UK
2004                 Ad Hoc Reviewer, Neurobiology C Study Section, Medical Research Service, Department of Veterans Affairs Administration
2003                 Ad Hoc Reviewer, research grants, Foundation Fighting Blindness, Canada
2002 - Present Ad Hoc Reviewer, research grants, Foundation Fighting Blindness, USA
2001                 Ad Hoc Reviewer, postdoctoral training grant, Research into Aging, UK
2000                 Ad Hoc Reviewer, Medical Research Service, Department of Veterans Affairs Administration
2007                 Special emphasis panel, Gene environment Initiative, National Human Genome Research Institute, NIH
2007                 CIDR Access Review Panel, National Human Genome Research Institute, NIH
2007                 Special emphasis panel, National Eye Institute, NIH
2007                 Ad Hoc Reviewer, research grants, Macular Disease Society, UK

  1. PROFESSIONAL COMMUNITY ACTIVITIES
      1. Advisory Board, Genentech, Age-related macular degeneration
      2. Co-organizer, “Genetics of Molecular Biology of Retinal Diseases”, ancillary meeting of Annual Meeting of American Society of Human Genetics.
      3. Organizer, “Snowbird Neuroscience Symposium 2006”
  1. Chief Medical Editor, Ophthalmology New and World Report, China Edition.
  2. Section Chair, Animal  Model of Age-Related macular Degeneration.  PreARVO Meeting 2007 on Retinal Degeneration and gene Therapy.
  1. UNIVERSITY COMMUNITY ACTIVITIES
    1. College Level

2005 - Present      Member, SOM Academic Senate Nominating Committee, Elected appointment by the Dean
2004 - Present      Member, SOM Admissions Committee
2007-present        Member, MD-PhD program Admissions Committee

    1. Department Level

2005 - Present      Director, Ophthalmology and Visual Sciences, Division of Ophthalmic Genetics
2005 - Present      Co-Director, Ophthalmology and Visual Sciences, Division of International Ophthalmology
2006-Present        Chair, resident research committee
2002 – Present     Member, Ophthalmology and Visual Sciences, Resident Selection Committee
2002 - Present      Member, Ophthalmology and Visual Sciences, Department Library Committee
2002 - Present      Member, Ophthalmology and Visual Sciences, Department Seminar Speaker Committee

    1. Other Internal Level

2001 -2002           Member, Cleveland Clinic Foundation, Search Committee for the Director for the Center for Human Genetics and Genomics
1991 -1995           Member, Harvard University - M.I.T., M.D. Curriculum Committee, Division of Health Sciences and Technology
1988 -1989           President, Harvard University, Chinese Student Association

  1. CURRENT MEMBERSHIPS IN PROFESSIONAL SOCIETIES

American Academy of Ophthalmology
American Association for the Advancement of Science
American Society of Clinical Investigation
American Society of Human Genetics
Association for Research in Vision and Ophthalmology
Macula Society

  1. TEACHING RESPONSIBILITIES/ASSIGNMENTS
    1. Course Lectures

2005-pres             Frontiers in Neuroscience, PhD Program in Neuroscience, University of Utah, Salt Lake City, UT; Contributing lecturer
2005                    Visiting Professor, King Khaled Eye Specialty Hospital. Riyahd, Saudi Arabia
2004                    Faculty Research Topic Lecture Series, PhD., Program in Molecular Biology, University of Utah, Salt Lake City, UT; Contributing lecturer
2003 - Present      Visiting Professor, Peking University Eye Center, Peking University, China
2003 - Present      Visiting Professor, Sichuan University, China
2003 - Present      Visiting Professor, Sichuan academy of Medical Sciences and Sichman Provincial Hospital, China
2003 - Present      Visiting Professor, Zhong Shan Ophthalmic Center, Sun Yet-sen University, China
2002 - Present      Fluorescein Angiogram Conference, John Moran Eye Center, University of Utah, Salt Lake City, UT; Contributing lecturer
2002 - Present      Grand Rounds, John Moran Eye Center, University of Utah, Salt Lake City, UT; Contributing lecturer
2002 - Present      Ophthalmology Resident Lectures - Lecture Series on the Retina, John Moran Eye Center, University of Utah, Salt Lake City, UT; Contributing lecturer
2000 -2002           Grand Rounds Quiz for residents, Cole Eye Institute, Cleveland Clinic
1992 -1994           Teaching Assistant in HMS-M.I.T. HST Genetics and Medicine, 80 students (MIT undergraduate and graduate students, Harvard Medical Students)

    1. Students Supervised

2005 - Present      Asif Azimi, MD, Postdoctoral fellow
2005 - Present      Jay Meyer, University of Utah Medical Student
2005 - Present      Nathan Faulkner, University of Utah Medical Student
2005 - Present      Rusten Gomez, University of Utah Undergraduate Student
2005 - Present      Shan Duan, PhD, Postdoctoral fellow
2005 - Present      Wendy Rao, University of Utah Undergraduate Student
2004                    Mac Machan, University of Utah Undergraduate Student
2004                    Nathan Faulkner, University of Utah Undergraduate Student
2004                    Parley Filmore, University of Illinois Medical Student
2004 - Present      Bradley Katz, MD, PhD. Post Doctoral Fellow, NIM K23 Mentored Clinician-Scientist Awardee
2004 - 2007          Josh Cameron, Neuroscience Program, University of Utah PhD Thesis Student
2007 – present     Ryan Constinine, Neuroscience Program, University of Utah PhD Thesis Student (MD/PhD)
2007 – present     Charity Olson, Molecular Biology Program, University of Utah PhD Thesis Student
2007 – present     Nikhil Banerjee, , Molecular Biology Program, University of Utah PhD Thesis Student (MD/PhD)
2004 - Present      Shin Kamaya, University of Utah Undergraduate Student
2004 - Present      Yali Chen, PhD, Postdoctoral fellow
2004 - Present      Zongzhong Tong, PhD, Postdoctoral Fellow
2003                    Kristina Price, Emery University Medical Student
2003                    Marrielle Payne, University of Utah Medical Student
2003                    Yian Yin, University of Utah Medical Student
2003 -2005           Chunmei Li, MD, Postdoctoral fellow, Staff Physician, Zhongshan Ophthalmic center, China
2003 - Present      Jianbin Hu, MD, Postdoctoral fellow
2002 - Present      Ophthalmology Attending. Supervising ophthalmology residents (PGY2-4), Moran Eye Center, Univ. of Utah
2002 - Present      Ophthalmology Attending. Supervising residents (PGY2-4) in retina and retina laser clinic, VA Hospital
2002 -2003           Jieyan Pan, PhD, Senior Postdoctoral fellow, University of Penn
2002 -2003           Keke Fan, PhD, Senior Postdoctoral fellow, Case Western University
2002 -2003           Lin Gan, MD, Senior Postdoctoral fellow, University of Heidelberg
2002 -2004           Li Jiang, MD, Postdoctoral Fellow/PhD Student,
Dept of Biology, University of Utah
2002 - Present      Goutam Karan, PhD, Postdoctoral fellow
2001                    Wei Lin, Harvard Medical Student
2000 -2001           Zhengya Yu, M.D., Prior Postdoctoral student, Assoc. Prof. Surgery and Chief of Vascular Surgery, Tong Reng Eye Hospital, Beijing, China
2000 -2002           Ophthalmology Attending. Supervised residents (PGY3-4), Cole Eye Institute, Cleveland Clinic Foundation
2000 -2001           Zhengya Yu, MD, Postdoctoral Fellow, Assoc. Prof. Surgery and Chief of Vascular Surgery, Tong Reng Eye Hospital, Beijing, China
2000 - Present      Zhenglin Yang, MD, Postdoctoral fellow
1999 -2000           Ophthalmology Attending. Supervised residents (PGY3-4), Wilmer Eye Institute, Johns Hopkins Hospital
1999 -2001           Yang Li, M.D., Prior Postdoctoral student, Assoc. Prof. Ophthalmology and Director of Research, Tong Reng Eye Hospital, Beijing, China
1999 -2001           Yang Li, MD, Postdoctoral Fellow, Assoc. Prof. Ophthalmology and Director of Research, Tong Reng Eye Hospital, Beijing, China
1993                    Edward Nugyen (Harvard College), UCSF Medical Student
1993                    Kristin Lictenberg (Wellesley College), Medical Student, University of Pittsburg Medical School
1992                    Howard Yeon (Harvard College), Harvard Medical Student

    1. Continuing Education

CME Courses Taught
2005     Diabetic Retinopathy, Department of Public Health. Idaho State University, Boise, Idaho
2003     Clinical Faculty Day, John Moran Eye Center, University of Utah School of Medicine. Salt Lake City, Utah

Bibliography

  1. ORIGINAL PUBLICATIONS
    1. Peer-Reviewed Publications
      1. Kapler GM, Zhang K, Beverley SM. (1987) Sequence and S1 nuclease mapping of the 5' region of the dihydrofolate reductase-thymidylate synthase gene of Leishmania major. Nucleic Acids Res, 15(8), 3369-83.
      2. Kapler GM, Zhang K, Beverley SM. (1990) Nuclease mapping and DNA sequence analysis of transcripts from the dihydrofolate reductase-thymidylate synthase (R) region of Leishmania major. Nucleic Acids Res, 18(21), 6399-408.
      3. Perkins LA, Doctor JS, Zhang K, Stinson L, Perrimon N, Craig EA. (1990) Molecular and developmental characterization of the heat shock cognate 4 gene of Drosophila melanogaster. Mol Cell Biol, 10(6), 3232-8.
      4. Zhang K, Chaillet JR, Perkins LA, Halazonetis TD, Perrimon N. (1990) Drosophila homolog of the mammalian jun oncogene is expressed during embryonic development and activates transcription in mammalian cells. Proc Natl Acad Sci U S A, 87(16), 6281-5.
      5. Zhang K, Smouse D, Perrimon N. (1991) The crooked neck gene of Drosophila contains a motif found in a family of yeast cell cycle genes. Genes Dev, 5(6), 1080-91.
      6. Rutledge BJ, Zhang K, Bier E, Jan YN, Perrimon N. (1992) The Drosophila spitz gene encodes a putative EGF-like growth factor involved in dorsal-ventral axis formation and neurogenesis. Genes Dev, 6(8), 1503-17.
      7. Zhang K, Bither PP, Park R, Donoso LA, Seidman JG, Seidman CE. (1994) A dominant Stargardt's macular dystrophy locus maps to chromosome 13q34. Arch Ophthalmol, 112(6), 759-64.
      8. Hata Y, Duh E, Zhang K, Robinson GS, Aiello LP. (1998) Transcription factors Sp1 and Sp3 alter vascular endothelial growth factor receptor expression through a novel recognition sequence. J Biol Chem, 273(30), 19294-303.
      9. Kniazeva M, Chiang MF, Morgan B, Anduze AL, Zack DJ, Han M, Zhang K. (1999) A new locus for autosomal dominant stargardt-like disease maps to chromosome 4. Am J Hum Genet, 64(5), 1394-9.
      10. Kniazeva MF, Chiang MF, Cutting GR, Zack DJ, Han M, Zhang K. (1999) Clinical and genetic studies of an autosomal dominant cone-rod dystrophy with features of Stargardt disease. Ophthalmic Genet, 20(2), 71-81.
      11. Zhang K, Garibaldi DC, Kniazeva M, Albini T, Chiang MF, Kerrigan M, Sunness JS, Han M, Allikmets R. (1999) A novel mutation in the ABCR gene in four patients with autosomal recessive Stargardt disease. Am J Ophthalmol, 128(6), 720-4.
      12. Zhang K, Jampel HD. (1999) Discordance of primary infantile glaucoma in monozygotic twins. Am J Ophthalmol, 128(1), 97-8.
      13. Zhang K, Kniazeva M, Hutchinson A, Han M, Dean M, Allikmets R. (1999) The ABCR gene in recessive and dominant Stargardt diseases: a genetic pathway in macular degeneration. Genomics, 60(2), 234-7.
      14. Allikmets R. (2000) Further evidence for an association of ABCR alleles with age-related macular degeneration. The International ABCR Screening Consortium. Am J Hum Genet, 67(2), 487-91.
      15. Kniazeva M, Traboulsi EI, Yu Z, Stefko ST, Gorin MB, Shugart YY, O'Connell JR, Blaschak CJ, Cutting G, Han M, Zhang K. (2000) A new locus for dominant drusen and macular degeneration maps to chromosome 6q14. Am J Ophthalmol, 130(2), 197-202.
      16. Stefko ST, Zhang K, Gorin MB, Traboulsi EI. (2000) Clinical spectrum of chromosome 6-linked autosomal dominant drusen and macular degeneration. Am J Ophthalmol, 130(2), 203-8.
      17. Ayyagari R, Zhang K, Hutchinson A, Yu Z, Swaroop A, Kakuk LE, Seddon JM, Bernstein PS, Lewis RA, Tammur J, Yang Z, Li Y, Zhang H, Yashar BM, Liu J, Petrukhin K, Sieving PA, Allikmets R. (2001) Evaluation of the ELOVL4 gene in patients with age-related macular degeneration. Ophthalmic Genet, 22(4), 233-9.
      18. Bernstein PS, Tammur J, Singh N, Hutchinson A, Dixon M, Pappas CM, Zabriskie NA, Zhang K, Petrukhin K, Leppert M, Allikmets R. (2001) Diverse macular dystrophy phenotype caused by a novel complex mutation in the ELOVL4 gene. Invest Ophthalmol Vis Sci, 42(13), 3331-6.
      19. Li Y, Marcos I, Borrego S, Yu Z, Zhang K, Antinolo G. (2001) Evaluation of the ELOVL4 gene in families with retinitis pigmentosa linked to the RP25 locus. J Med Genet, 38(7), 478-80.
      20. Wilkie SE, Li Y, Deery EC, Newbold RJ, Garibaldi D, Bateman JB, Zhang H, Lin W, Zack DJ, Bhattacharya SS, Warren MJ, Hunt DM, Zhang K. (2001) Identification and functional consequences of a new mutation (E155G) in the gene for GCAP1 that causes autosomal dominant cone dystrophy. Am J Hum Genet, 69(3), 471-80.
      21. Zhang K, Kniazeva M, Han M, Li W, Yu Z, Yang Z, Li Y, Metzker ML, Allikmets R, Zack DJ, Kakuk LE, Lagali PS, Wong PW, MacDonald IM, Sieving PA, Figueroa DJ, Austin CP, Gould RJ, Ayyagari R, Petrukhin K. (2001) A 5-bp deletion in ELOVL4 is associated with two related forms of autosomal dominant macular dystrophy. Nat Genet, 27(1), 89-93.
      22. Yang Z, Peachey NS, Moshfeghi DM, Thirumalaichary S, Chorich L, Shugart YY, Fan K, Zhang K. (2002) Mutations in the RPGR gene cause X-linked cone dystrophy. Hum Mol Genet, 11(5), 605-11.
      23. Zhang K, Garibaldi DC, Li Y, Green WR, Zack DJ. (2002) Butterfly-shaped pattern dystrophy: a genetic, clinical, and histopathological report. Arch Ophthalmol, 120(4), 485-90.
      24. Johnson S, Halford S, Morris AG, Patel RJ, Wilkie SE, Hardcastle AJ, Moore AT, Zhang K, Hunt DM. (2003) Genomic organisation and alternative splicing of human RIM1, a gene implicated in autosomal dominant cone-rod dystrophy (CORD7). Genomics, 81(3), 304-14.
      25. Kniazeva M, Sieber M, McCauley S, Zhang K, Watts JL, Han M. (2003) Suppression of the ELO-2 FA elongation activity results in alterations of the fatty acid composition and multiple physiological defects, including abnormal ultradian rhythms, in Caenorhabditis elegans. Genetics, 163(1), 159-69.
      26. Yang Z, Lin W, Moshfeghi DM, Thirumalaichary S, Li X, Jiang L, Zhang H, Zhang S, Kaiser PK, Traboulsi EI, Zhang K. (2003) A novel mutation in the RDS/Peripherin gene causes adult-onset foveomacular dystrophy. Am J Ophthalmol, 135(2), 213-8.
      27. Zhang XM, Yang Z, Karan G, Hashimoto T, Baehr W, Yang XJ, Zhang K. (2003) Elovl4 mRNA distribution in the developing mouse retina and phylogenetic conservation of Elovl4 genes. Mol Vis, 9301-7.
      28. Berry V, Yang Z, Addison PK, Francis PJ, Ionides A, Karan G, Jiang L, Lin W, Hu J, Yang R, Moore A, Zhang K, Bhattacharya SS. (2004) Recurrent 17 bp duplication in PITX3 is primarily associated with posterior polar cataract (CPP4). J Med Genet, 41(8), e109.
      29. Hunt DM, Wilkie SE, Newbold R, Deery E, Warren MJ, Bhattacharya SS, Zhang K. (2004) Dominant cone and cone-rod dystrophies: functional analysis of mutations in retGC1 and GCAP1. Novartis Found Symp, 25537-49; discussion 49-50, 177-8.
      30. Karan G, Yang Z, Zhang K. (2004) Expression of wild type and mutant ELOVL4 in cell culture: subcellular localization and cell viability. Mol Vis, 10248-53.
      31. Maugeri A, Meire F, Hoyng CB, Vink C, Van Regemorter N, Karan G, Yang Z, Cremers FP, Zhang K. (2004) A novel mutation in the ELOVL4 gene causes autosomal dominant Stargardt-like macular dystrophy. Invest Ophthalmol Vis Sci, 45(12), 4263-7.
      32. Payne M, Yang Z, Katz BJ, Warner JE, Weight CJ, Zhao Y, Pearson ED, Treft RL, Hillman T, Kennedy RJ, Meire FM, Zhang K. (2004) Dominant optic atrophy, sensorineural hearing loss, ptosis, and ophthalmoplegia: a syndrome caused by a missense mutation in OPA1. Am J Ophthalmol, 138(5), 749-55.
      33. Toomes C, Bottomley HM, Jackson RM, Towns KV, Scott S, Mackey DA, Craig JE, Jiang L, Yang Z, Trembath R, Woodruff G, Gregory-Evans CY, Gregory-Evans K, Parker MJ, Black GC, Downey LM, Zhang K, Inglehearn CF. (2004) Mutations in LRP5 or FZD4 underlie the common familial exudative vitreoretinopathy locus on chromosome 11q. Am J Hum Genet, 74(4), 721-30.
      34. Toomes C, Bottomley HM, Scott S, Mackey DA, Craig JE, Appukuttan B, Stout JT, Flaxel CJ, Zhang K, Black GC, Fryer A, Downey LM, Inglehearn CF. (2004) Spectrum and frequency of FZD4 mutations in familial exudative vitreoretinopathy. Invest Ophthalmol Vis Sci, 45(7), 2083-90.
      35. Xu Q, Wang Y, Dabdoub A, Smallwood PM, Williams J, Woods C, Kelley MW, Jiang L, Tasman W, Zhang K, Nathans J. (2004) Vascular development in the retina and inner ear: control by Norrin and Frizzled-4, a high-affinity ligand-receptor pair. Cell, 116(6), 883-95.
      36. Yang Z, Li Y, Jiang L, Karan G, Moshfeghi D, O'Connor S, Li X, Yu Z, Lewis H, Zack D, Jacobson S, Zhang K. (2004) A novel RDS/peripherin gene mutation associated with diverse macular phenotypes. Ophthalmic Genet, 25(2), 133-45.
      37. Berthelemy-Okazaki N, Zhao Y, Yang Z, Camp NJ, Farnham J, Parker D, Tsuruda J, Macdonald J, Zhang K, Cannon-Albright LA. (2005) Examination of ELN as a candidate gene in the Utah intracranial aneurysm pedigrees. Stroke, 36(6), 1283-4.
      38. Jiang L, Katz BJ, Yang Z, Zhao Y, Faulkner N, Hu J, Baird J, Baehr W, Creel DJ, Zhang K. (2005) Autosomal dominant cone dystrophy caused by a novel mutation in the GCAP1 gene (GUCA1A). Mol Vis, 11143-51.
      39. Karan G, Lillo C, Yang Z, Cameron DJ, Locke KG, Zhao Y, Thirumalaichary S, Li C, Birch DG, Vollmer-Snarr HR, Williams DS, Zhang K. (2005) Lipofuscin accumulation, abnormal electrophysiology, and photoreceptor degeneration in mutant ELOVL4 transgenic mice: a model for macular degeneration. Proc Natl Acad Sci U S A, 102(11), 4164-9.
      40. Karan G, Yang Z, Howes K, Zhao Y, Chen Y, Cameron DJ, Lin Y, Pearson E, Zhang K. (2005) Loss of ER retention and sequestration of the wild-type ELOVL4 by Stargardt disease dominant negative mutants. Mol Vis, 11657-64.
      41. Li C, Kosmorsky G, Zhang K, Katz BJ, Ge J, Traboulsi EI. (2005) Optic atrophy and sensorineural hearing loss in a family caused by an R445H OPA1 mutation. Am J Med Genet A, 138(3), 208-11.
      42. Pauer GJ, Xi Q, Zhang K, Traboulsi EI, Hagstrom SA. (2005) Mutation screen of the membrane-type frizzled-related protein (MFRP) gene in patients with inherited retinal degenerations. Ophthalmic Genet, 26(4), 157-61.
      43. Yang Z, Alvarez BV, Chakarova C, Jiang L, Karan G, Frederick JM, Zhao Y, Sauve Y, Li X, Zrenner E, Wissinger B, Hollander AI, Katz B, Baehr W, Cremers FP, Casey JR, Bhattacharya SS, Zhang K. (2005) Mutant carbonic anhydrase 4 impairs pH regulation and causes retinal photoreceptor degeneration. Hum Mol Genet, 14(2), 255-65.
      44. Bidinost C, Matsumoto M, Chung D, Salem N, Zhang K, Stockton DW, Khoury A, Megarbane A, Bejjani BA, Traboulsi EI. (2006) Heterozygous and homozygous mutations in PITX3 in a large Lebanese family with posterior polar cataracts and neurodevelopmental abnormalities. Invest Ophthalmol Vis Sci, 47(4), 1274-80.
      45. Chen H, Chen Y, Horn R, Yang Z, Wang C, Turner MJ, Zhang K. (2006) Clinical features of autosomal dominant retinitis pigmentosa associated with a Rhodopsin mutation. Ann Acad Med Singapore, 35(6), 411-5.
      46. Katz BJ, Yang Z, Payne M, Lin Y, Zhao Y, Pearson E, Duan S, Kamaya S, Karan G, Zhang K. (2006) Fundus appearance of choroideremia using optical coherence tomograpy. Adv Exp Med Biol, 57257-61.
      47. Katz BJ, Zhang K. (2006) Juxtapapillary hemangioblastoma as a manifestation of von Hippel-Lindau disease. Pediatr Int, 48(4), 423-5.
      48. Katz BJ, Zhao Y, Warner JE, Tong Z, Yang Z, Zhang K. (2006) A family with X-linked optic atrophy linked to the OPA2 locus Xp11.4-Xp11.2. Am J Med Genet A, 140(20), 2207-11.
      49. Li Y, Wang G, Dong B, Sun X, Turner MJ, Kamaya S, Zhang K. (2006) A novel mutation of the VMD2 gene in a Chinese family with best vitelliform macular dystrophy. Ann Acad Med Singapore, 35(6), 408-10.
      50. Magnusson KP, Duan S, Sigurdsson H, Petursson H, Yang Z, Zhao Y, Bernstein PS, Ge J, Jonasson F, Stefansson E, Helgadottir G, Zabriskie NA, Jonsson T, Bjornsson A, Thorlacius T, Jonsson PV, Thorleifsson G, Kong A, Stefansson H, Zhang K, Stefansson K, Gulcher JR. (2006) CFH Y402H confers similar risk of soft drusen and both forms of advanced AMD. PLoS Med, 3(1), e5.
      51. Nozaki M, Raisler BJ, Sakurai E, Sarma JV, Barnum SR, Lambris JD, Chen Y, Zhang K, Ambati BK, Baffi JZ, Ambati J. (2006) Drusen complement components C3a and C5a promote choroidal neovascularization. Proc Natl Acad Sci U S A, 103(7), 2328-33.
      52. Sauve Y, Karan G, Yang Z, Li C, Hu J, Zhang K. (2006) Treatment with carbonic anhydrase inhibitors depresses electroretinogram responsiveness in mice. Adv Exp Med Biol, 572439-46.
      53. Tong Z, Yang Z, Meyer JJ, McInnes AW, Xue L, Azimi AM, Baird J, Zhao Y, Pearson E, Wang C, Chen Y, Zhang K. (2006) A novel locus for X-linked retinitis pigmentosa. Ann Acad Med Singapore, 35(7), 476-8.
      54. Wang C, Hu J, Bernstein PS, Teske MP, Payne M, Yang Z, Li C, Adams D, Baird JH, Zhang K. (2006) Intravitreal injection of triamcinolone acetonide for macular edema due to retinitis pigmentosa and other retinal diseases. Adv Exp Med Biol, 572309-14.
      55. Wang C, Katz BJ, Turner MJ, Hu J, Zhang K. (2006) Intravitreal triamcinolone acetonide for the treatment of diffuse diabetic macular oedema--a case report. Ann Acad Med Singapore, 35(2), 112-4.
      56. Yang Z, Camp NJ, Sun H, Tong Z, Gibbs D, Cameron DJ, Chen H, Zhao Y, Pearson E, Li X, Chien J, Dewan A, Harmon J, Bernstein PS, Shridhar V, Zabriskie NA, Hoh J, Howes K, Zhang K. (2006) A variant of the HTRA1 gene increases susceptibility to age-related macular degeneration. Science, 314(5801), 992-3.
      57. Alvarez BV, Vithana EN, Yang Z, Koh AH, Yeung K, Yong V, Shandro HJ, Chen Y, Kolatkar P, Palasingam P, Zhang K, Aung T, Casey JR. (2007) Identification and characterization of a novel mutation in the carbonic anhydrase IV gene that causes retinitis pigmentosa. Invest Ophthalmol Vis Sci, 48(8), 3459-68.
      58. Cameron DJ, Tong Z, Yang Z, Kaminoh J, Kamiyah S, Chen H, Zeng J, Chen Y, Luo L, Zhang K. (2007) Essential role of Elovl4 in very long chain fatty acid synthesis, skin permeability barrier function, and neonatal survival. Int J Biol Sci, 3(2), 111-9.
      59. Cameron DJ, Yang Z, Gibbs D, Chen H, Kaminoh Y, Jorgensen A, Zeng J, Luo L, Brinton E, Brinton G, Brand JM, Bernstein PS, Zabriskie NA, Tang S, Constantine R, Tong Z, Zhang K. (2007) HTRA1 Variant Confers Similar Risks to Geographic Atrophy and Neovascular Age-related Macular Degeneration. Cell Cycle, 6(9), 1122-5.
      60. Fu L, Garland D, Yang Z, Shukla D, Rajendran A, Pearson E, Stone EM, Zhang K, Pierce EA. (2007) The R345W Mutation in EFEMP1 is Pathogenic, and Causes AMD-Like Deposits in Mice. Hum Mol Genet,
      61. Li W, Chen Y, Cameron DJ, Wang C, Karan G, Yang Z, Zhao Y, Pearson E, Chen H, Deng C, Howes K, Zhang K. (2007) Elovl4 haploinsufficiency does not induce early onset retinal degeneration in mice. Vision Res, 47(5), 714-22.
      62. Tuo J, Bojanowski CM, Zhou M, Shen D, Ross RJ, Rosenberg KI, Cameron DJ, Yin C, Kowalak JA, Zhuang Z, Zhang K, Chan CC. (2007) Murine ccl2/cx3cr1 deficiency results in retinal lesions mimicking human age-related macular degeneration. Invest Ophthalmol Vis Sci, 48(8), 3827-36.
      63. Yu J, Wiita P, Kawaguchi R, Honda J, Jorgensen A, Zhang K, Fischetti VA, Sun H. (2007) Biochemical analysis of a common human polymorphism associated with age-related macular degeneration. Biochemistry, 46(28), 8451-61.
  1. Non Peer-Reviewed Publications
  2. 1.   Hunt DM, Wilkie SE, Newbold R, Deery E, Warren MJ, Bhattacharya SS, Zhang K. (2004). Dominant cone and cone-rod dystrophies: functional analysis of mutations in retGC1 and GCAP1. Novartis Found Symp255, 37-49; discussion 49-50, 177-8.
  1. REVIEW ARTICLES
      1. Garibaldi D, Zhang K. (1999). Molecular genetics of macular degeneration. Intl Ophthal. Clinics39, 117.
      2. Zhang K, Yeon H, Han M, Donoso LA. (1996). Molecular genetics of macular dystrophies. Br J Ophthalmol80(11), 1018-22.
      3. Zhang K, Nguyen E, Crandall A, Donoso LA. (1995). Genetic and molecular studies of macular dystrophies: recent development. Survey of Ophthalmology40, 51.
      4. Zhang K, Wang MX, Munier F, Roth D, Mastrangelo D, Chung S, Shields JA, Donoso LA. (1993). Molecular genetics of retinoblastoma. Int Ophthalmol Clin33(3), 53-65.
  1. BOOK CHAPTERS

1.   Moshfeghi DM, Yang Z, Faulkner ND, Karan G, Hirumalaichary S, Jiang L, Tsai T, Zhang K. (2005). Choroidal Neovascularization in Patients with Adult-onset Foveomacular Dystrophy Caused by Mutations in the RDS/Peripherin Gene: Report of 3 Cases. In Hollyfield JG, Anderson RE, LaVail MM (Eds.), Retinal Degeneration: Clinical and Laboratory Applications. New York: Plenum Publishing Corporation.
2.   Katz BJ, Yang Z, Payne M, Zhang K. (2005). Fundus Appearance of Choroideremia. In Hollyfield JG, Anderson RE, LaVail MM (Eds.), Retinal Degeneration: Clinical and Laboratory Applications. New York: Plenum Publishing Corporation.
3.   Zhang K, Carr RE, Sunness JS. (2005). Hereditary chorodial dystrophies. In Ryan SJ (Ed.), Retina.
4.   Hu J, Payne M, Zhang K. (2005). Intravitreal Injection of Triamcinolone Acetonide for Macular Edema Due to Retinitis Pigmentosa and Other Retinal Diseases. In Hollyfield JG, Anderson RE, LaVail MM (Eds.), Retinal Degeneration: Clinical and Laboratory Applications. New York: Plenum Publishing Corporation.
5.   Sauve Y, Karan G, Yang Z, Li C, Hu J, Zhang K. (2005). Treatment with Carbonic Anhydrase Inhibitors Depresses Electroretinogram Responsiveness in Mice. In Hollyfield JG, Anderson RE, LaVail MM (Eds.), Retinal Degeneration: Clinical and Laboratory Applications.
6.   Zhang K, Carr RE, Sunness JS. (2001). Hereditary choroidal dystrophies. In Ryan SJ (Ed.), Retina.
7.   Li Y, Lam L, Yu Z, Yang Z, Bither P, Zhang K. (2000). Clinical spectrum of autosomal dominant Stargardt's macular dystrophy with a mutation in ELOVL4. In Hollyfield JG, Anderson RE, LaVail MM (Eds.), Retinal Degeneration: Clinical and Laboratory Applications. New York: Plenum Publishing Corporation.
8.   Garibaldi GC, Yang Z, Li Y, Yu Z, Zhang K. (2000). The role of fatty acids in the pathogenesis of retinal degeneration. In Hollyfield JG, Anderson RE, LaVail MM (Eds.), Retinal Degeneration: Clinical and Laboratory Applications. New York: Plenum Publishing Corporation.

  1. OTHER (Commentary/Letters/Editorials/Case Reports/Video/Film)

Patents
1.   Zhang K. (Provisional patent filed 2004). CA4 for adRP and AMD. Washington, D.C.:U.S. Patent and Trademark Office.
2.   Zhang K, Petrukhin WL. (Provisional patent filed 2004). ELOVL4 gene.  Patent No. 2067809999. Washington, D.C.:U.S. Patent and Trademark Office.
3.   Zhang K. (Provisional patent filed 2004). ELOVL4 transgenic mice as a model for macular degeneration. Washington, D.C.:U.S. Patent and Trademark Office.

  1. ORAL PRESENTATIONS
    1. Invited/Visiting Professor Presentations

International
2008        International Symposium on Retinal Degeneration
2008        Macular Vision Research Foundation Symposium
                     2007     University of Alberta
2007      Annual Meeting of Chinese Ophthalmology Society, Beijing, China
2007      Chinese Bioscience Symposium, Beijing
2007      Institute of ophthalmology, University College London
2007      Trinity College, Ireland
2006      Osaka Bioscience Institute, Japan
2006      Annual Meeting of Chinese Ophthalmology Society, Beijing, China
2005      Annual Meeting of Chinese Ophthalmology Society. Beijing, China
2004      Beijing Ophthalmology Symposium.
2003      Institute of Ophthalmology, Univ. College London.
2002      University of Nimjagen, Netherlands.
2000      Singapore National Eye Research Institute, Singapore.
National
2007      Angiogenesis 2007, FL
                     2007        Foundation Fighting Blindness, Orlando, FL
2005      Macular Vision Research Foundation Symposium.
2004      Steinbach Macular Degeneration Symposium.
2003      FASCEB Conference.
2002      Steinbach Macular Degeneration Symposium.
2001      III Retina Summit, Cleveland, OH.
2001      7th Great Lake Vision Research Conference, Cleveland, OH.
2000      Foundation Fighting Blindness, Ft. Lauderdale, FL.
Local/Regional
2007        Brigham and Women’s Hospital/Harvard Medical School
2007     Joslin Diabetes Center/Harvard Medical School
2007      Univ. of Kentucky, Dept. of Ophthalmology & Visual Sciences
2003      Oklahoma University, Dept. of Ophthalmology & Visual Sciences
2002      University of Utah, Moran Eye Center.
2002      UCLA, Jules Stein Eye Institute.
2002      Ohio State University, Dept. of Ophthalmology.
1995      University of Colorado, Health Science Center.
1994      Mass. Eye & Ear Infirmary, Harvard Medical School.

 

 

Last updated: January 26, 2005

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