Lori A. Wagner, Ph.D.

Research Assistant Professor of Dermatology

B.S., 1984, University of Utah
Ph.D., 1994, University of Utah
Post-doctoral, 1993-1995, Fred Hutchinson Cancer Research Center, Seattle, WA (Genomics)
Post-doctoral, 1996-1998, Fred Hutchinson Cancer Research Center (Cell Biology)

Research Interests
Research interests include the function of the eosinophil in disease and the development of novel treatments for allergic diseases and asthma. My approach to treating atopic disease has been to study the development of eosinophil precursors in the bone marrow in the hope of finding new target molecules for novel drugs. I have discovered a novel RNA gene involved in eosinophil development, named EGO. In addition, I am interested in developing T cell epitope vaccines against allergic diseases and the treatment of Hypereosinophilic syndrome.

Selected Publications
Wagner LA, Ohnuki LE, Parsawar K, Gleich GJ, Nelson CC. (2007). Human Eosinophil Major Basic Protein 2: Location of Disulfide Bonds and Free Sulfhydryl Groups. The Protein Journal, 26 (1), 13-8.

Wagner LA, Christensen CJ, Dunn DM, Spangrude GJ, Georgelas A, Kelley L, Esplin MS, Weiss RB, Gleich GJ. (2007). EGO, a novel non-coding RNA gene, regulates eosinophil granule protein expression. Blood, 109 (12), 5191-8.,br />
Pegorier S, Wagner LA, Gleich GJ, Pretolani M. (2006). Eosinophil-derived cationic proteins activate the synthesis of remodeling factors by airway epithelial cells. J Immunol, 177(7), 4861-9.

Ohnuki LE, Wagner LA, Georgelas A, Loegering DA, Checkel JL, Plager DA, Gleich GJ. (2005). Differential extraction of eosinophil granule proteins. J Immunol Methods, 307(1-2), 54-61.

Wagner LA, Brown T, Gil S, Frank I, Carter W, Tamura R, Wayner EA. (1999). The keratinocyte-derived cytokine IL-7 increases adhesion of the epidermal T cell subset to the skin basement membrane protein laminin-5. Eur J Immunol, 29(8), 2530-8.

Szabo CI, Wagner LA, Francisco LV, Roach JC, Argonza R, King MC, Ostrander EA. (1996). Human, canine and murine BRCA1 genes: sequence comparison among species. Hum Mol Genet, 5(9), 1289-98.

Wagner LA, Gesteland RF, Dayhuff TJ, Weiss RB. (1994). An efficient Shine-Dalgarno sequence but not translation is necessary for lacZ mRNA stability in Escherichia coli. J Bacteriol, 176(6), 1683-8.

Wagner LA, Weiss RB, Driscoll R, Dunn DS, Gesteland RF. (1990). Transcriptional slippage occurs during elongation at runs of adenine or thymine in Escherichia coli. Nucleic Acids Res, 18(12), 3529-35.