Sancy A. Leachman, M.D., Ph.D.
Associate Professor of Dermatology
B.A., 1985, University of Texas at Austin
M.D., Ph.D., 1993, University of Texas Southwestern
Internship in Internal Medicine, 1993-1994, University of Texas Southwestern
Residency in Dermatology, 1994-1997, Yale University
Fellowship in Cutaneous Oncology, 1997-1998, Yale University
Board Certification in Dermatology
Clinical and Research Interests
Dr. Leachman is interested in the treatment and scientific investigation of skin cancer, with a special emphasis on inherited cancer syndromes and familial melanoma. She is director of the Tom C. Mathews Jr. Familial Melanoma Research Clinic that is dedicated to the investigation of human melanoma. Her research centers around molecular mechanisms involved in the development of skin cancer andfocuses primarily on the familial melanoma syndrome. Her clinical practice is primarily composed of patients with pigmentary disorders such as vitiligo and patients with familial cancer syndromes such as the familial melanoma syndrome, Cowden's syndrome, and Peutz-Jeger's syndrome.
In addition to genetic skin cancer syndromes, Dr. Leachman also has an interest in rare genetic disorders that affect the skin. Her primary non-cancer focus has been on the ultra-rare autosomal dominant keratin disorder, pachyonychia congenita. She is chair of the International Pachyonychia Congenita Consortium, a worldwide consortium of physicians and scientists dedicated to improving care for these patients. She is working with TransDerm, Inc. and PC-Project (a public charity for pachyonychia congenita) to test a novel siRNA-based therapeutic agent in pachyonychia congenita patients.
Selected Publications
Leachman SA and Brandsma JL. Nucleic acid vaccines for immunization against papillomavirus induced lesions. In: Human Papillomavirus Vaccines. 1998. Ed. By R Tindle, Landes Bioscience, Austin, Texas.
Leachman SA, Insogna KL, Katz L, Ellison A, Milstone LM. Bone densities in patients receiving isotretinoin for cystic acne. Arch Dermatol 1999;135:961-965
Leachman SA, Tigelaar RE, Shylankevich M, Slade M, Irwin M, Chang E, Xiao W, Pazhani S, Zelterman D, and Brandsma JL. GM-CSF priming plus papillomavirus E6 DNA vaccination: Effects on papilloma formation and regression in the CRPV-rabbit model. J Virol 2000;74:8700-8708
Leachman SA. Surgical Therapies, part III: Melanocyte Transplants. In: Dermatologic Therapy. 2001. Ed. Jean Bolognia, Blackwell Science, Vol 14:20-28
Florell SR, Coffin CM, Holden JA, Zimmermann JW, Gerwels JW, Summers BK, Jones DA, and Leachman SA. Preservation of RNA for functional genomic studies: A multidisciplinary tumor bank protocol. Modern Pathol 2001;14:116-128
Hanson N, Leachman SA. Safety Issues in Isotretinoin Therapy. Semin Cutan Med Surg 2001;20:166-183
Leachman SA, Shylankevich M, Slade MD, LeVine D, Sundaram R, Xiao W, Zelterman D, Tigelaar RE, and Brandsma JL. Ubiquitin-fused and/or multiple early genes from cottontail rabbit papillomavirus as DNA vaccines. J Virol 2002;76:7616-7624
Agarwal-Antal N, Zimmerman J, Scholz T, Noyes RD, Leachman SA. Case report of a giant verruciform xanthoma. J Cutan Path 2002;29:119-124
Florell SR, Boucher KM, Holden JA, Meyer LJ, Samlowski WE, Cannon-Albright LA, Zone JJ, Leachman SA. Failure todetect differences in proliferation status in nevi from CDKN2Amutation carriers and non-carriers. J Invest Dermatol 2002;118:386-387
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