The Division of Medical
Ethics and Humanities

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Key Cases & Events in Medical Ethics

Ethics of Experimentation
August 19, 1947

Twenty Nazi physicians and three medical administrators are charged with "murders, tortures and other atrocities committed in the name of medical science."
Ethical dilemma: Raises specter of human guinea pigs and whether knowledge gained from experiments should be used.

DNA - The Secret of Life
April 25, 1953

The scientific magazine Nature publishes a one-page paper entitled "The molecular Structure of Nucleic Acids" by James D. Watson and Francis H. Crick, laying out the biochemical structure and function of DNA.
Ethical dilemma: Raises questions about how this knowledge will be used.

Renal Transplantation
December 23, 1954

Dr. Joseph E. Murray sutured a kidney excised from a 24 year-old man into his identical twin at Peter Bent Brigham Hospital in Boston. The recipient lived for eight more years, eventually dying of coronary artery disease. Murray's bold surgery inaugurated the era of major organ transplantation.
Ethical dilemma: Who qualifies for an organ transplant? Who makes the decisions?

Chronic Hemodialysis, Seattle Dialysis Selection Committee
March 9, 1960

Clyde Shields, a 39 year-old machinist dying of kidney failure, is the first patient to be connected to a hemodialysis machine.
Ethical dilemma: How to meet the needs of 20,000 people annually in the U.S. who suffer from end-stage renal disease. And, at a cost of $10,000 a year in 1960 dollars, how to pay for the treatments?

Oral Contraceptive
May, 1960

The U.S. Food and Drug Administration approves the first effective oral contraceptive.
Ethical dilemma: Physicians have discretion to prescribe oral contraceptive to prevent pregnancy.

Heart Transplantation
December 3, 1967

South African Surgeon Christiaan Bernard takes a beating heart from Denise Darvall, a car accident victim, an places it in the chest of 55 year-old Louis Washkansky. Washkansky dies 18 days later.
Ethical dilemma: Death was when the heart stopped beating and breathing ceased. Now, continued circulation is necessary to preserve a viable organ for transplantation.

Definition of Death
August 5, 1968

Harvard Medical School committee proposes "brain death" as the definition of death.
Ethical dilemma: Many states adopted "brain death" as the new definition of death, but some did not. For a while it was possible to be dead in one state and not in another.

Informed Patients
1970

Theologian Paul Ramsey publishes The Patient as Person after spending a year in Georgetown University Hospital, leading to the recognition of the need for informed consent.
Ethical dilemma: Raises specter of human guinea pigs and whether knowledge gained from experiments should be used.

The Tuskegee Revelations
July 26, 1972

A story in the The New York Times reports that during a 40 year study on the effects of syphilis conducted in Tuskegee, Alabama, African-American men were not given treatment so the effects of the disease could be observed.
Ethical dilemma: Revelations bring the horrors of the Nazi medical experiments, which many had judged impossible in the United states, into our scientific and medical worlds.

Roe v. Wade
January 22, 1973

The U.S. Supreme Court in Roe v. Wade holds that state law cannot restrict the right of a woman, in accord with her doctor, to obtain an abortion during the first trimester of pregnancy, justifying its ruling under the right of privacy implied in the Bill of Rights.
Ethical dilemma: When does life begin? The question becomes central to the field of bioethics.

Karen Ann Quinlan
March 31, 1976

Courts grant the parents of Karen Ann Quinlan, a 21 year-old New Jersey woman who became comatose after ingesting alcohol and barbiturates, the right to remove her from life support.
Ethical dilemma: American doctors begin to look at the ethical dimensions of decisions to withhold or withdraw life-sustaining medical treatment.

Louis Joy Brown
July 25, 1978

The first test-tube baby is born.
Ethical dilemma: Issues about ownership of fertilized embryos, rightful claims of parenthood among multiple contributors to a child's being, and preimplantation research and diagnosis stretched the bounds of public policy and the law.

Fetal Tissue Ruling
1981

The Reagan Administration bans experiments using fetal tissue.
Ethical dilemma: How is research into causes of baby deaths to proceed?

Baby Doe
Spring, 1982

Parents of a Bloomington, Indiana baby with Down's syndrome decline surgery to correct a blocked intestine, leading to the baby's death. Reagan Administration establishes "Baby Doe" regulations for newborn intensive care units.
Ethical dilemma: This added the ethics of newborn care to the debate.

Artificial Heart Implanted
December, 1982

Seattle dentist Barney Clark is kept alive on an artificial heart at the University of Utah's Health Sciences Center.
Ethical dilemma: Who decides how to use the technology and who should pay for the costs?

The AIDS Epidemic
April 11, 1983

Newsweek magazine publishes first public discussion of AIDS.
Ethical dilemma: How to arrive at a public policy for the prevention and treatment of the disease? Who pays for it?

Baby Fae
1984

A baboon heart is transplanted into newborn Baby Fae in Loma Linda, California. She dies a few days later.
Ethical dilemma: When does medical benefit become medical experimentation?

The Baby M
1986

The Baby M surrogate-mother case blurs the definition of parenthood, morally and legally.
Ethical dilemma: How to redefine parenthood.

Funding Priorities
1987

Oregon passes a law giving funding priority to basic health care rather than expensive technological treatments such as transplants.
Ethical dilemma: Do critically ill patients have any less right to medical care? Where do doctors and hospitals draw the line on providing care?

Right to Die
1989

The parents of Nancy Cruzan, an adult comatose woman, request removal of her feeding tube. The U.S. Supreme Court rules that others can decide on behalf of a presently incompetent patient, but that states can decide what level of evidance is necessary to substantiate a decision based on patient preference. Missouri chooses the standard of "clear and convincing evidence". As additional evidence of Nancy's preference emerges the prosecution drops the case; Cruzan is allowed to die.
Ethical dilemma: Does the standard lie with courts, parent/guardian wishes or medical expertise?

Death with Dignity Act
1994

Oregon's law allows physicians to prescribe enough medication to hasten the death of a terminally ill patient at his or her request.
Ethical dilemma: How is what Oregon physicians are allowed to do different from Dr. Kevorkian's practices? Should policy be federally mandated?

Hello Dolly, Dolly
February, 1997

Dolly the sheep is cloned in England.
Ethical dilemma: How far should cloning of species go?

Embryonic Cells
1998

Research of stem sells from an intact embryo spawns debate about the embryo.
Ethical dilemma: When does an embryo become a being that shouldn't be tampered with?

The Human Genome
June, 2000

Scientists complete a rough draft of the human genome sequence, calling it a "glimpse into the instruction book" that makes us human.
Ethical dilemma: What is next in the ability to alter or manipulate the human "instruction book"?

Adapted with permission from an article in the Salt Lake Tribune, Saturday November 18, 2000.

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